{
  "abstract": "Background Acute kidney injury requiring dialysis (AKI-D) is a major contributor to morbidity and mortality worldwide, with the highest burden observed in low- and lower-middle-income countries (LLMICs). In Latin America (LATAM), a region composed largely of LLMICs, the lack of region-specific data leads to variable clinical practices and inconsistent health policies for AKI, which remain major barriers to optimal kidney care. The LATAM-AKID registry aims to fill this gap and systematically characterise the epidemiology, processes of care and outcomes of patients with AKI-D across representative countries of LATAM.Methods and analysis LATAM-AKID is an international, multicentre, retrospective cohort study that will enrol consecutive critically ill adults with Kidney Disease: Improving Global Outcomes stage 3 AKI requiring dialysis. Different hospitals across 10 Latin American countries will contribute data through a standardised REDCap platform hosted at the University of Alabama at Birmingham. Deidentified data will be collected at baseline, intensive care unit (ICU) admission and renal replacement therapy (RRT) initiation, with follow-up for up to 7 days to capture ICU- and RRT-related clinical data. Study outcomes will be assessed at ICU and hospital discharge and at 90-day follow-up. The primary outcome is in-hospital mortality. Secondary outcomes include ICU mortality, 90-day mortality, ICU and hospital lengths of stay, status of renal recovery and RRT dependence at hospital discharge and at 90-day follow-up, and RRT processes and complications related to anticoagulation, catheter dysfunction, infection and circuit interruptions. Data will be analysed using multivariable logistic and Cox regression models, with planned subgroup analyses by RRT modality (continuous vs intermittent), patient-level illness severity, hospital characteristics and country gross national income categories.Ethics and dissemination This study has been approved by the institutional review board of the University of Alabama at Birmingham (IRB-300013633). Local ethics committee approvals will also be obtained at all participating sites. Results from this work will be disseminated by publications in peer-reviewed journals and presentations at national and international scientific meetings.Trial registration number This study has been registered with clinicaltrials.gov ( NCT07262320).",
  "authors": [
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Aqeeb Ur Rehman"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Natalia Nombera-Aznaran"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA",
        "Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy"
      ],
      "name": "Stefania Renzi"
    },
    {
      "affiliations": [
        "Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Lama Ghazi"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Ashita J Tolwani"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, La Cardio, Fundación Cardioinfantil, Universidad del Rosario, Bogotá, Colombia"
      ],
      "name": "Alejandra Molano Trivino"
    },
    {
      "affiliations": [
        "Division of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil",
        "CPQuali Pesquisa Clínica, Clinical Research Center, São Paulo, Brazil"
      ],
      "name": "Thiago Reis"
    },
    {
      "affiliations": [
        "Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico"
      ],
      "name": "Olynka Vega-Vega"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University Hospital \"Jose Eleuterio Gonzalez\", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico"
      ],
      "name": "Lilia Rizo-Topete"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Medicine, Hospital Obrero No 2—Caja Nacional de Salud, Cochabamba, Plurinational State of Bolivia"
      ],
      "name": "Rolando Claure-Del Granado"
    },
    {
      "affiliations": [
        "Division of Nephrology, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"
      ],
      "name": "Javier A Neyra"
    }
  ],
  "title": "LATAM-AKID registry: an international multicentre, observational study of acute kidney injury requiring dialysis in Latin America",
  "uid": "af670230-1753-5d5c-9b3d-bbfb3c5508fe"
}