{
  "abstract": "Purpose The BioCaPPE (Biomarkers of Prostate Cancer/Prevention and Environment) study is a multicentre prospective observational cohort designed to identify biomarkers associated with prostate cancer (PCa) risk that may be modifiable through lifestyle factors. This paper describes the cohort, along with the data and bio-samples available for future studies in PCa risk assessment.Participants Canadian men at risk of PCa were enrolled based on one of two criteria (1) negative first prostate biopsy within 6 months from enrolment (Group 1); or (2) a prostate-specific antigen (PSA) blood level between 2.5 and 10 ng/mL without prior prostate biopsy (Group 2). At baseline, blood samples and comprehensive data were collected. PCa incidence and lifestyle factors were updated for all participants over 2 years, with extended follow-up for those who provided additional consent.Findings to date Recruitment was conducted across four health centres in Quebec, Canada. A total of 2053 men were enrolled—1499 in Group 1 and 554 in Group 2. All participants completed the initial visit, which included collection of medical and family history, anthropometric measurements, demographic information, dietary and alcohol intake, physical activity, tobacco use, medication use, and quality of life assessments, and candidate biomarker measurements. At the 2-year mark, 7.2% of participants had developed PCa; this figure has since increased to 15.3% (median follow-up: 6.1 years). Additionally, 84% (n=1718) consented to ongoing annual follow-up.Future plans This large, prospective cohort of men at risk of PCa offers valuable resources for risk stratification and primary prevention. The BioCaPPE biosamples and data are available to support the identification of lifestyle-related biomarkers associated with PCa risk in this population.Trial registration number ClinicalTrials.gov Identifier: NCT03383016.",
  "authors": [
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Hanane Moussa"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Roxane Tourigny"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Karine Robitaille"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada"
      ],
      "name": "Vanessa Bussières"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Jonathan Fadel"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Farah Ben Souilah"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Lamoussa Diabaté"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada"
      ],
      "name": "Hélène Hovington"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada"
      ],
      "name": "Laurence Bettan"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Louis Lacombe"
    },
    {
      "affiliations": [
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Thierry Dujardin"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Michele Lodde"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Paul Toren"
    },
    {
      "affiliations": [
        "McGill University Health Centre, Montreal, Quebec, Canada"
      ],
      "name": "Armen Aprikian"
    },
    {
      "affiliations": [
        "Université de Montréal, Centre Hospitalier de l’Université de Montréal, Montreal, Quebec, Canada"
      ],
      "name": "Fred Saad"
    },
    {
      "affiliations": [
        "Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada"
      ],
      "name": "Michel Carmel"
    },
    {
      "affiliations": [
        "Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada"
      ],
      "name": "Claudio Jeldres"
    },
    {
      "affiliations": [
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Benoit Lamarche"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada"
      ],
      "name": "Alain Bergeron"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Yves Fradet"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Université Laval, Québec City, Quebec, Canada",
        "Oncology Program, CHU de Québec-Université Laval Research Center, Québec City, Quebec, Canada",
        "Centre NUTRISS - Nutrition santé et société, Université Laval, Québec City, Quebec, Canada",
        "Centre de Recherche sur le Cancer, Universite Laval, Quebec, Quebec, Canada",
        "Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec City, Quebec, Canada",
        "Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec City, Quebec, Canada"
      ],
      "name": "Vincent Fradet"
    },
    {
      "affiliations": [],
      "name": "Network BIOCaPPE"
    }
  ],
  "title": "Cohort profile: BioCaPPE (Biomarkers of Prostate Cancer/Prevention and Environment) – a Canadian multicentre prospective study of lifestyle and candidate biomarkers in relation to prostate cancer risk",
  "uid": "6fcfdc15-d7d0-5257-ba1e-4defe7082bc4"
}