{
  "abstract": "Objectives Trauma-focused cognitive behavioural therapy (TF-CBT) is the established first-line treatment for paediatric post-traumatic stress disorder (PTSD), but access to evidence-based care remains limited. This study aimed to evaluate the feasibility and acceptability of a therapist-guided, 12 week, internet-delivered TF-CBT (iTF-CBT) programme for adolescents with PTSD and to explore preliminary changes in PTSD symptoms.Design Single-group feasibility trial.Setting Save the Children, Sweden.Participants Twenty-two adolescents (13–17 years, 82% female) with primary PTSD.Interventions A 12 week, therapist-guided, asynchronous, internet-delivered TF-CBT comprising eight modules and parallel caregiver modules with joint adolescent–caregiver activities.Outcomes Feasibility measures included recruitment pace, participant retention, treatment adherence (module completion) and therapist time. Acceptability was evaluated through satisfaction, credibility, negative effects and reported adverse events. Within-group changes in PTSD severity using independent evaluator-rated Clinician-Administered PTSD Scale (CAPS-CA-5) and the self-reported Child and Adolescent Trauma Screen 2 (CATS-2) were used as indicators of potential clinical change. Assessments occurred at baseline, during treatment, post-treatment and at 1 month follow-up (primary endpoint).Results Recruitment was completed after 7 months of active enrolment. Retention and adherence were high, satisfaction and credibility ratings were favourable, and no intervention-related serious adverse events occurred. Within-group improvements were observed at the primary endpoint, with large reductions on CAPS-CA-5 (Cohen’s d=1.27) and CATS-2 (Cohen’s d=1.51). At follow-up, 47.6% of participants no longer met criteria for PTSD.Conclusions Therapist-guided iTF-CBT for adolescents with PTSD was safe, feasible, acceptable and associated with potentially meaningful symptom improvements. These findings support further evaluation in larger, controlled trials to determine efficacy, cost-effectiveness and long-term outcomes.Trial registration number NCT06185244.",
  "authors": [
    {
      "affiliations": [
        "Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Sweden",
        "Save the Children, Stockholm, Stockholm County, Sweden"
      ],
      "name": "Erica Mattelin"
    },
    {
      "affiliations": [
        "Save the Children, Stockholm, Stockholm County, Sweden",
        "Department of Clinical Neuroscience, Karolinska Institute Centre for Psychiatry Research, Stockholm, Sweden"
      ],
      "name": "Hanna Weyler"
    },
    {
      "affiliations": [
        "Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Sweden"
      ],
      "name": "Rebecca Andersson"
    },
    {
      "affiliations": [
        "Save the Children, Stockholm, Stockholm County, Sweden"
      ],
      "name": "Josefine Paulsen"
    },
    {
      "affiliations": [
        "Save the Children, Stockholm, Stockholm County, Sweden"
      ],
      "name": "Sandra Tielman"
    },
    {
      "affiliations": [
        "Save the Children, Stockholm, Stockholm County, Sweden"
      ],
      "name": "Anna Vikgren"
    },
    {
      "affiliations": [
        "National Centre for Disaster Psychiatry, Uppsala University Department of Medical Sciences, Uppsala, Uppsala County, Sweden"
      ],
      "name": "Kristina Bondjers"
    },
    {
      "affiliations": [
        "Department of Clinical Neuroscience, Karolinska Institute Centre for Psychiatry Research, Stockholm, Stockholm County, Sweden",
        "Department of Clinical Sciences, Lund University Faculty of Medicine, Lund, Skåne County, Sweden",
        "Department of Child and Adolescent Psychiatry, Skåne University Hospital Lund, Lund, Skåne County, Sweden",
        "Department of Child and Adolescent Psychiatry, Aarhus University Hospital Psychiatry, Aarhus, Central Denmark Region, Denmark"
      ],
      "name": "Eva Serlachius"
    },
    {
      "affiliations": [
        "Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Sweden",
        "Department of Clinical Sciences, Lund University Faculty of Medicine, Lund, Skåne County, Sweden"
      ],
      "name": "David Mataix-Cols"
    },
    {
      "affiliations": [
        "Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Sweden"
      ],
      "name": "Maria Bragesjö"
    }
  ],
  "title": "Feasibility and acceptability of therapist-guided, asynchronous, internet-delivered trauma-focused CBT for adolescents with PTSD: a single-group feasibility trial in Sweden",
  "uid": "866183d5-1770-5e12-89d1-82793d7a5bb1"
}