{
  "abstract": "Introduction Recurrence of acute pancreatitis (AP) is common, leading to cumulative pancreatic injury and reduced quality of life. While aetiology-based treatments and lifestyle interventions are effective, long-term adherence is often poor due to insufficient health awareness and a lack of continuous reminders. We designed the PROGRESS ( PROactive GRadEd follow-up Strategy for reducing recurrence in acute pancreatitiS) trial to evaluate whether a physician-initiated, proactive and graded follow-up strategy can reduce AP recurrence.Methods and analysis The PROGRESS trial is a multicentre, open-label, randomised controlled trial. A total of 194 patients with AP will be randomised 1:1 to either a proactive follow-up group or a standard follow-up group. In the proactive follow-up group, patients are stratified into high-risk or low-risk categories based on reported risk factors. Follow-up is conducted via WeChat with varying frequencies: every 3 months for the high-risk group and every 6 months for the low-risk group. The standard follow-up group receives routine discharge education and a 1-month outpatient visit. The primary endpoint is the number of AP recurrence episodes within 24 months post-discharge. Secondary endpoints include AP recurrence rate, progression to chronic pancreatitis, quality of life (Short Form 12 Health Survey), anxiety/depression scores (Generalized Anxiety Disorder-7/Patient Health Questionnaire-9), readmission rates and mortality. Analysis will follow the intention-to-treat principle.Ethics and dissemination This study has been approved by the Ethics Committee of Peking Union Medical College Hospital (No. I-25PJ2556, I-26PJ0895). Ethics approval of each participating centre is required before initiation of patient enrolment. The results of this study will be published in peer-reviewed journals.Trial registration number ChiCTR2500113459 (Chinese Clinical Trial Registry).",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Yingyu Pan"
    },
    {
      "affiliations": [
        "Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Yuelun Zhang"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Zihan Yang"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Yonghao Chen"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Yiyang Min"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Xiaoxuan Huang"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Shengyu Zhang"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Jianing Li"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Dong Wu"
    }
  ],
  "title": "Proactive graded follow-up strategy for reducing recurrence in acute pancreatitis (PROGRESS): protocol for a multicentre, randomised controlled trial",
  "uid": "102580a0-d041-55dc-8aa6-4ee91a9e2680"
}