{
  "abstract": "Introduction Hepatocellular carcinoma (HCC) recurs in most patients after curative treatment. Late recurrence (>2 years after curative treatment) typically indicates de novo tumours in the residual liver. Although contrast-enhanced computed tomography (CECT) and MRI are widely used for post-treatment follow-up, they each have limitations including radiation exposure, high cost and limited access. The abbreviated MRI using gadoxetic acid versus multiphasic CECT for detection of late recurrent HCC after curative treatment (AMRICT) trial aims to compare gadoxetic acid-enhanced abbreviated MRI using hepatobiliary phase imaging (HBP-AMRI) and multiphasic CECT for detecting late recurrent HCC after curative treatment.Methods and analysis This prospective multicentre intra-individual comparison trial will enrol 455 participants who have undergone surgical resection or local ablation for HCC and remained recurrence-free for over 2 years. Each participant will undergo two imaging sessions at 6±2 month intervals, using both HBP-AMRI and multiphasic CECT. The primary endpoint is the detection rate of all-stage HCC. The secondary endpoints include the false referral rate of all-stage HCC and detection and false referral rates of Barcelona Clinic Liver Cancer stage 0–A HCC and of stage 0 HCC. Structured imaging protocols and quality assessments will be implemented for both modalities.Ethics and dissemination This study was approved by the Institutional Review Boards of the three participating institutions (approval number: 2023–1630 (Asan Medical Center), H-2407-146-1556 (Seoul National University Hospital) and B-2410-929-401 (Seoul National University Bundang Hospital)) and registered at ClinicalTrials.gov ( NCT06537193). Findings will be disseminated through peer-reviewed journals, scientific meetings, public forums and guideline updates.Trial registration number ClinicalTrials.gov: NCT06537193. Participant enrolment began on 12 December 2024, and is ongoing.",
  "authors": [
    {
      "affiliations": [
        "Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Republic of Korea"
      ],
      "name": "Hyo Jung Park"
    },
    {
      "affiliations": [
        "Department of Radiology, Seoul National University Hospital, Jongno-gu, Republic of Korea"
      ],
      "name": "Dong Ho Lee"
    },
    {
      "affiliations": [
        "Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea"
      ],
      "name": "Won Chang"
    },
    {
      "affiliations": [
        "Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Republic of Korea"
      ],
      "name": "Hae Young Kim"
    },
    {
      "affiliations": [
        "Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Republic of Korea"
      ],
      "name": "Dong Hwan Kim"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Won-Mook Choi"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Sung Won Chung"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Jonggi Choi"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Danbi Lee"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Ju Hyun Shim"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Han Chu Lee"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Liver Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Young-Suk Lim"
    },
    {
      "affiliations": [
        "Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea"
      ],
      "name": "Seon-Ok Kim"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"
      ],
      "name": "Amit G Singal"
    },
    {
      "affiliations": [
        "Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Republic of Korea"
      ],
      "name": "So Yeon Kim"
    }
  ],
  "title": "Multicentre prospective trial of abbreviated MRI using gadoxetic acid versus CT for detection of late recurrent HCC (AMRICT): study protocol",
  "uid": "9dbd5dc2-5ad7-5c59-bfe8-f5c598d2979f"
}