{
  "abstract": "Introduction Pathologic myopia (PM) is a leading cause of irreversible blindness worldwide, yet effective therapeutic interventions remain limited. Although repeated low-level red light (RLRL) therapy has demonstrated significant efficacy in controlling myopia progression among children, its application in patients with PM remains unexplored. This study aims to evaluate the regulatory effects of RLRL on choroidal vascular density and thickness in patients with PM and verify its safety and efficacy in delaying the progression of fundus atrophic lesions.Methods and analysis This is a prospective, randomised, controlled trial enrolling 158 patients with PM aged 18–55 years. Participants will be randomised (1:1) to an intervention group or a control group. The intervention group will receive light-emitting diode–based RLRL therapy (wavelength, 660 nm; power density, 65 mW/cm²) administered two times daily for 3 min per session, 5 days per week, over a 12-month period. The control group will receive a sham treatment (power density, 5 mW/cm²) following an identical schedule. The primary outcome measure is the change in choroidal vascular density and choroidal vessel volume index at 12 months.Ethics and dissemination This study has been approved by the Ethics Review Committee of Shanghai Eye Disease Prevention and Treatment Centre (EC-20250506-04). This study will be conducted in adherence to the approved protocol, Good Clinical Practice and the Declaration of Helsinki. The study results will be submitted to a peer-reviewed journal and presented at both local and international congresses.Trial registration number NCT07312214",
  "authors": [
    {
      "affiliations": [
        "Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China",
        "Eye Public Health Research Center, School of Medicine, Tongji University, Shanghai, China"
      ],
      "name": "Juzhao Zhang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Jun Yu"
    },
    {
      "affiliations": [
        "National Clinical Research Center for Eye Diseases, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Xiaojuan Wang"
    },
    {
      "affiliations": [
        "Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China"
      ],
      "name": "Tao Sun"
    },
    {
      "affiliations": [
        "Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China"
      ],
      "name": "Yue-lan Zou"
    },
    {
      "affiliations": [
        "Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China",
        "Eye Public Health Research Center, School of Medicine, Tongji University, Shanghai, China",
        "National Clinical Research Center for Eye Diseases, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Haidong Zou"
    },
    {
      "affiliations": [
        "Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China",
        "Eye Public Health Research Center, School of Medicine, Tongji University, Shanghai, China"
      ],
      "name": "Yan Xu"
    }
  ],
  "title": "LED red light for atrophy and microcirculation in pathologic myopia (RAMP): study design and protocol for a multicentre randomised controlled trial",
  "uid": "851fa61c-8995-55c0-8eed-940ba0b3177d"
}