{
  "abstract": "Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe, multisystem condition that often emerges after viral infections and affects physical and cognitive function. Severely affected patients are underrepresented in research due to immobility and exertional intolerance.Methods This is a prospective, non-interventional observational study investigating the feasibility and tolerability of home-based diagnostics in patients with severe and very severe ME/CFS. Phase 1 includes remote identification using validated questionnaires. Phase 2 involves home visits for physiological, cognitive and biological assessments. The primary outcome is feasibility; secondary outcomes include tolerability and methodological barriers.Ethics/dissemination The study protocol was approved by the Ethics Committee of the University of Freiburg (No. 25-1031-S1). Written informed consent is obtained from all participants. Results will be disseminated via peer-reviewed publications and patient support groups.Trial registration number DRKS00035231; FRKS005506.",
  "authors": [
    {
      "affiliations": [
        "Institut für Bewegungs- und Arbeitsmedizin, Universitätsklinikum Freiburg, Freiburg, Germany"
      ],
      "name": "Carmen Fricke"
    },
    {
      "affiliations": [
        "University of Freiburg, Freiburg im Breisgau, Germany"
      ],
      "name": "Peter Deibert"
    },
    {
      "affiliations": [
        "Institut für Bewegungs- und Arbeitsmedizin, Universitätsklinikum Freiburg, Freiburg, Germany"
      ],
      "name": "Philipp Maier"
    },
    {
      "affiliations": [
        "Universitätsklinikum Freiburg, Freiburg, Germany"
      ],
      "name": "Winfried Kern"
    },
    {
      "affiliations": [
        "Institut für Bewegungs- und Arbeitsmedizin, Universitätsklinikum Freiburg, Freiburg, Germany"
      ],
      "name": "Oliver Krumnau"
    },
    {
      "affiliations": [
        "Institut für Bewegungs- und Arbeitsmedizin, Universitätsklinikum Freiburg, Freiburg, Germany"
      ],
      "name": "Friedrich Barsch"
    }
  ],
  "title": "ACHTSAM study protocol: outreach diagnostics and assessment of tolerability in severe ME/CFS—a pilot study",
  "uid": "aa3611ec-747e-5c06-a9d5-e0094fca3ba9"
}