{
  "abstract": "Introduction Non-communicable diseases are the leading causes of premature mortality worldwide. Both genetic predispositions and environmental exposures affect disease risk. While biobanks have increased understanding of genetic predictors of these diseases, environmental influences are expected to have a greater impact on disease development. Individuals also create their own environments and lifestyles based on genetically regulated preferences, leading to gene–environment interactions that require large datasets to study. Finnish biobanks typically lack sufficient lifestyle and environmental data, which limits their use. We present a protocol for a biobank-recall study (BioRecall) to collect data on lifestyle and environmental exposures and combine these findings with genotypes, biological samples and clinical outcomes.Methods and analysis All previously genotyped donors from the Central Finland Biobank who have been diagnosed with type 2 diabetes and have consented to recall will be invited to participate in the pilot study. The preliminary feasibility assessment reveals that there are 1580 suitable candidates. Participants will complete an electronic questionnaire on a secure online platform. The questionnaire includes validated questions on lifestyles, anthropometrics, weight loss history, health, symptoms, work characteristics, emotional states and residential environments. Postcode information will facilitate the addition of spatial environmental data. Genotype and related clinical data will be provided in the study in accordance with the Finnish Biobank Act and combined with questionnaire data.Ethics and dissemination The Human Sciences Ethics Committee of the University of Jyväskylä delivered a favourable statement regarding the study protocol (1671/13.00.04.00/2023). Central Finland Biobank approved the research plan (no: BB24-0333-A01). The data collected will be returned to the Central Finland Biobank for research purposes with the participants’ consent. Permission for data usage can then be applied through standard protocols of the Fingenious service ( https://site.fingenious.fi/en/). If successful, the study will be expanded to other donors and Finnish biobanks.",
  "authors": [
    {
      "affiliations": [
        "University of Jyväskylä Faculty of Sports and Health Sciences, Jyväskylä, Finland",
        "Wellbeing Services County of Central Finland, Jyväskylä, Finland"
      ],
      "name": "Elina Sillanpää"
    },
    {
      "affiliations": [
        "University of Jyväskylä Faculty of Sports and Health Sciences, Jyväskylä, Finland"
      ],
      "name": "Tiina Föhr"
    },
    {
      "affiliations": [
        "University of Jyväskylä Open Science Centre, Jyväskylä, Finland",
        "University of Jyväskylä Faculty of Humanities and Social Sciences, Jyväskylä, Finland"
      ],
      "name": "Elisa Kurtti"
    },
    {
      "affiliations": [
        "University of Eastern Finland Institute of Public Health and Clinical Nutrition, Kuopio, Finland",
        "Unit of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland"
      ],
      "name": "Kirsikka Aittola"
    },
    {
      "affiliations": [
        "Finnish Biobank Cooperative, Turku, Finland"
      ],
      "name": "Johanna Mäkelä"
    },
    {
      "affiliations": [
        "Finnish Biobank Cooperative, Turku, Finland",
        "University of Turku Faculty of Law, Turku, Finland"
      ],
      "name": "Tom Southerington"
    },
    {
      "affiliations": [
        "University of Eastern Finland Institute of Biomedicine, Kuopio, Finland",
        "Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland",
        "Foundation for Research in Health Exercise and Nutrition, Research Institute of Exercise Medicine, Kuopio, Finland"
      ],
      "name": "Timo A Lakka"
    },
    {
      "affiliations": [
        "Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland",
        "Central Finland Biobank, Wellbeing Services County of Central Finland, Jyväskylä, Finland"
      ],
      "name": "Tiina Jokela"
    },
    {
      "affiliations": [
        "Central Finland Biobank, Wellbeing Services County of Central Finland, Jyväskylä, Finland"
      ],
      "name": "Maarit Ahtiainen"
    },
    {
      "affiliations": [
        "University of Jyväskylä Faculty of Sports and Health Sciences, Jyväskylä, Finland",
        "Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland"
      ],
      "name": "Eija Laakkonen"
    },
    {
      "affiliations": [
        "University of Jyväskylä Faculty of Sports and Health Sciences, Jyväskylä, Finland",
        "Wellbeing Services County of Central Finland, Jyväskylä, Finland",
        "Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland"
      ],
      "name": "Merja Rantakokko"
    },
    {
      "affiliations": [
        "University of Jyväskylä Faculty of Sports and Health Sciences, Jyväskylä, Finland",
        "Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland"
      ],
      "name": "Suvi Ravi"
    }
  ],
  "title": "Genetic, lifestyle and environmental influences on health: a Finnish biobank recall study protocol (BioRecall)",
  "uid": "fe150088-21f4-5522-95d4-87d7d3201831"
}