{
  "abstract": "Introduction This systematic review aims to synthesise current evidence on gut microbiome profiles among children with sickle cell disease (SCD), assess the influence of analgesic and antibiotic use, and explore the contributions of environmental factors on their gut microbiota diversity. Through identification of consistent microbial patterns and gaps in the existing literature, this review will provide vital insight into potential microbiome-targeted strategies for improving health outcomes in paediatric SCD care.Methods and analysis Studies describing the gut microbiota among paediatric SCD human subjects (<18 years) will be identified by searching PubMed, Cochrane Library, Web of Science, Google Scholar and Scopus from inception to November 2025. Two independent reviewers will complete title and abstract screening, full-text review and data extraction. The grading of recommendations assessment, development and evaluation tool will be employed to assess the strength of evidence for each outcome. Extracted data will be presented in tables, and a meta-analysis will be conducted if appropriate.Ethics and dissemination Ethical approval will not be required as this is a systematic review of published data. The findings will be disseminated through publications in peer-reviewed journals and presentations at relevant scientific conferences.PROSPERO registration number CRD420251102736.",
  "authors": [
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Abideen Olurotimi Salako"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Joseph Ikeh Ogbeh"
    },
    {
      "affiliations": [
        "Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Hafeez Aderinsayo Adekola"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Olayemi Odubela"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria",
        "Public Health Department, Lead City University, Ibadan, Oyo, Nigeria"
      ],
      "name": "Folahanmi Akinsolu"
    },
    {
      "affiliations": [
        "Biochemistry and Nutrition Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Ruqqayah Jimoh"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Tomilola Ebunoluwa Musari-Martins"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Samson Luka"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "AbdulRasheed Oba"
    },
    {
      "affiliations": [
        "Solina Centre for International Developmenat and Research (SCIDaR), Abuja, FCT, Nigeria"
      ],
      "name": "Daniel Ayegbeso"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Oluwatosin Olaseni Odubela"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Titilola Abike Gbaja-Biamila"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria",
        "Monitoring and Evaluation Unit, Nigerian Institute of Medical Research, Lagos, Nigeria"
      ],
      "name": "Adesola Zaidat Musa"
    },
    {
      "affiliations": [
        "Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria",
        "College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria"
      ],
      "name": "Babatunde Lawal Salako"
    }
  ],
  "title": "Gut microbiome profile among children and adolescents living with sickle cell disease: a protocol for systematic review and meta-analysis",
  "uid": "012ab31b-eed6-5a7b-88d8-d41c543c6932"
}