{
  "abstract": "Objectives The role of the triglyceride–glucose body mass index (TyG-BMI) in glycaemic state transitions among individuals with pre-diabetes remains unclear. This study explores the association between cumulative average TyG-BMI and the likelihood of regression to normoglycaemia or progression to diabetes.Methods Participants with pre-diabetes from the China Health and Retirement Longitudinal Study were included. Pre-diabetes was defined using American Diabetes Association criteria. Cumulative average TyG-BMI was calculated using data from 2011 and 2015. Ordinal logistic regression and restricted cubic spline (RCS) analyses were used to evaluate the association between cumulative average TyG-BMI and glycaemic transitions.Results A total of 556 participants (mean age 58.5 years; 45.9% male) were included; 350 (62.9%) remained pre-diabetic, 111 (19.96%) reverted to normoglycaemia and 95 (17.09%) progressed to diabetes. After adjustment for confounding factors, higher cumulative average TyG-BMI was significantly associated with lower odds of regression to normoglycaemia and higher odds of progression to diabetes (OR=0.50; 95% CI 0.33 to 0.62; p<0.001). The RCS analysis demonstrated a negative linear relationship between cumulative average TyG-BMI and glycaemic improvement (p for overall <0.001, p for nonlinear=0.149).Conclusions Higher cumulative average TyG-BMI levels identify individuals with pre-diabetes who are less likely to revert to normoglycaemia and more likely to progress to diabetes, highlighting its value as a practical marker for early risk stratification and targeted clinical management of pre-diabetes.",
  "authors": [
    {
      "affiliations": [
        "Department of Geriatrics, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People’s Hospital, Shanghai, China"
      ],
      "name": "Ningling Dai"
    },
    {
      "affiliations": [
        "Department of Geriatrics, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People’s Hospital, Shanghai, China"
      ],
      "name": "Haiya Wang"
    }
  ],
  "title": "Association between the cumulative average triglyceride glucose–body mass index and glycaemic state transitions in adults with pre-diabetes: evidence from the CHARLS cohort",
  "uid": "c53891b1-fa6f-5e61-823c-36953f85bec4"
}