{
  "abstract": "Introduction Folic acid is crucial for fetal development, particularly during early pregnancy. Studies suggest that high folic acid intake (≥800 µg/day) may be associated with a reduced risk of miscarriage. However, the impact of an 800 µg dose on pregnancy outcomes in women with prior pregnancy loss currently remains unclear.Methods and analysis We will conduct a multi-centre randomised controlled study comparing 800 µg and 400 µg in women with previous pregnancy loss. The primary outcome is live birth. Secondary outcomes include early pregnancy loss, ongoing pregnancy at 24 gestation weeks, homocysteine (Hcy) reduction, maternal and perinatal outcomes. We plan to recruit 1116 women (558 women per group). Data analysis will follow the intention-to-treat principle and per-protocol. Subgroup analysis will be conducted based on Hcy levels, previous pregnancy losses and body mass index.Trial registration number ChiCTR2500100255.",
  "authors": [
    {
      "affiliations": [
        "Department of Reproductive medicine, Lanzhou University Second Hospital, Lanzhou, China"
      ],
      "name": "Cai Liu"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China"
      ],
      "name": "Zhuhua Cai"
    },
    {
      "affiliations": [
        "Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China"
      ],
      "name": "Lirong Du"
    },
    {
      "affiliations": [
        "Reproductive Medical Center, Shandong University of Traditional Chinese Medicine, Jinan, China"
      ],
      "name": "Zhou Fang"
    },
    {
      "affiliations": [
        "Department of Reproductive Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China"
      ],
      "name": "Hongjun Yang"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Pingliang Second People’s Hospital, Pingliang, China"
      ],
      "name": "Haiyan Wu"
    },
    {
      "affiliations": [
        "Department of Obstetrics, Tianshui First People’s Hospital, Tianshui, China"
      ],
      "name": "Qun Li"
    },
    {
      "affiliations": [
        "Department of Reproductive Medicine, Zhangye Second People’s Hospital, Zhangye, China"
      ],
      "name": "Aiqin Yan"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Longxi County Hospital of Traditional Chinese Medicine, Dingxi, China"
      ],
      "name": "Luming Chen"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynaecology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China"
      ],
      "name": "Ran An"
    },
    {
      "affiliations": [
        "Department of Reproductive Medicine, Henan Provincial People’s Hospital, Zhengzhou, China"
      ],
      "name": "Qiaohua He"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Longyang District Maternal and Child Health Hospital of Baoshan City, Baoshan, China"
      ],
      "name": "Xueqin Zhang"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynaecology, Longyang District Maternal and Child Health Hospital of Baoshan City, Baoshan, China"
      ],
      "name": "Yuefang Ren"
    },
    {
      "affiliations": [
        "Department of Reproductive medicine, Lanzhou University Second Hospital, Lanzhou, China"
      ],
      "name": "Fang Wang"
    }
  ],
  "title": "Effects of different folic acid supplementation doses on subsequent pregnancy outcomes in women with a history of pregnancy loss: study protocol for a multicentre randomised controlled trial",
  "uid": "5362f57f-7649-5cfb-b959-c46933b46564"
}