{
  "abstract": "Introduction Circadian rhythm disturbance is associated with neurologic, metabolic, cardiovascular and immune disorders. As the most reliable biomarker of endogenous circadian rhythms, melatonin regulates the sleep-wake cycle and promotes sleep. Studies have demonstrated that saliva and plasma melatonin levels show strong correlations in non-surgical populations. However, the relationship between salivary and plasma melatonin measurements in patients undergoing surgery is unknown. This study will analyse the correlation between the peak concentrations of salivary and blood melatonin in perioperative patients.Methods and analysis In this prospective study, 102 patients scheduled for thoracic or neurosurgical procedures are being enrolled. The primary outcome of this study is to analyse the correlation between the peak concentrations of salivary and plasma melatonin (measured at 04:00 on the first postoperative day) in patients.Ethics and dissemination The study protocol has been approved by the Medical Ethics Committee of Peking University Third Hospital (M2023009). The results of the study will be published in peer-reviewed international journals.Trial registration number The study has been registered at the Chinese Clinical Trial Registry ( www.chictr.org.cn) with identifier ChiCTR2300070470. The latest version of the trial protocol was approved in October 2023.",
  "authors": [
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Baixin Chen"
    },
    {
      "affiliations": [
        "School of Basic Medical Sciences, Peking University, Beijing, China"
      ],
      "name": "Shiqi Yuan"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Pihong Wei"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Fengyun Jing"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China"
      ],
      "name": "Mingke Zhu"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China"
      ],
      "name": "Xu Zhang"
    },
    {
      "affiliations": [
        "Department of Thoracic Surgery, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Yan Zhang"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Yuehua Zhang"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Huadong Wang"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Zifan Su"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Jia Yang"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Yehong Luo"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Yiming Liu"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Haokun Ning"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Zhengqian Li"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China"
      ],
      "name": "Xiangyang Guo"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Yanan Song"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai’an, Shandong, China"
      ],
      "name": "Zaiqi Yang"
    }
  ],
  "title": "The feasibility of salivary melatonin in assessing perioperative circadian rhythm in surgical patients: study protocol for a multicentre prospective study in China",
  "uid": "74c43456-713c-591b-83f8-e97bc909066f"
}