{
  "abstract": "Purpose The EPHOR-NIGHT cohort was established to investigate how night shift work influences biological pathways and chronic disease risk using a comprehensive working-life exposome approach, focusing on cardiometabolic, mental health, cognitive and biological ageing outcomes.Participant The cohort includes 937 workers aged 20–65 years (88% female), primarily from the healthcare sector (96%) in Spain, Sweden, Denmark and the Netherlands. Participants were categorised as permanent day (39%), permanent night (35%) or rotating/other shift workers (26%). Data collection included questionnaires, daily ecological momentary assessments, wearable sensors tracking light, physical activity, heart rate and environmental exposures and biological samples (blood collected once and saliva collected during five points across the day), with harmonised protocols across countries.Findings to date From the 937 participants contributing data to the cohort, 708 had complete information from questionnaires, sensors and blood and saliva, with subsets undergoing advanced biological analyses, including genomics, targeted and genome-wide DNA methylation, telomere length and mtDNA copy number, metabolomics, transcriptomics, proteomics, hormone profiling and inflammatory biomarkers and blood metals. Many reported prevalent chronic conditions, including anxiety (27%), depression (18%) and metabolic disturbances. Night shift and rotating shift workers had greater exposure to long shifts and more scheduled rest days compared with day workers. Sleep duration and quality were poorest among permanent night shift workers.Future plans A 2-year follow-up was completed in June 2025, including the collection of additional biomarker data, psychosocial work environment data and data related to female sexual and reproductive health. Findings from the EPHOR-NIGHT study aim to inform prevention strategies and occupational health policies. Data will be made available to support broader research efforts on shift work and health.",
  "authors": [
    {
      "affiliations": [
        "College of Population Health, The University of New Mexico, Albuquerque, New Mexico, USA",
        "Department of Non-Communicable Diseases and Environment, Instituto de Salud Global Barcelona, Barcelona, Catalunya, Spain"
      ],
      "name": "Barbara N Harding"
    },
    {
      "affiliations": [
        "Department of Non-Communicable Diseases and Environment, Instituto de Salud Global Barcelona, Barcelona, Catalunya, Spain",
        "Pompeu Fabra University, Barcelona, Spain",
        "CIBER Epidemiología y Salud Publica (CIBERESP), Madrid, Spain, Madrid, Community of Madrid, Spain",
        "IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"
      ],
      "name": "Gemma Castaño-Vinyals"
    },
    {
      "affiliations": [
        "Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden",
        "Department of Laboratory Medicine, Lund University, Lund, Skåne County, Sweden"
      ],
      "name": "Karin Broberg"
    },
    {
      "affiliations": [
        "Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden",
        "Department of Laboratory Medicine, Lund University, Lund, Skåne County, Sweden"
      ],
      "name": "Maria Albin"
    },
    {
      "affiliations": [
        "Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden"
      ],
      "name": "Caisa Laurell"
    },
    {
      "affiliations": [
        "National Research Centre for the Working Environment, Copenhagen, Capital Region of Denmark, Denmark",
        "Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark"
      ],
      "name": "Anne Helene Garde"
    },
    {
      "affiliations": [
        "National Research Centre for the Working Environment, Copenhagen, Capital Region of Denmark, Denmark",
        "Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark"
      ],
      "name": "Kirsten Nabe-Nielsen"
    },
    {
      "affiliations": [
        "National Research Centre for the Working Environment, Copenhagen, Capital Region of Denmark, Denmark"
      ],
      "name": "Anne Emily Saunte Fiehn"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Tara van der Grinten"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Susan Peters"
    },
    {
      "affiliations": [
        "Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"
      ],
      "name": "Roel C H Vermeulen"
    },
    {
      "affiliations": [
        "Environment and Health Unit, KU Leuven, Leuven, Flanders, Belgium"
      ],
      "name": "Manosij Gosh"
    },
    {
      "affiliations": [
        "Institute of Occupational Medicine, Edinburgh, Scotland, UK"
      ],
      "name": "Miranda Loh"
    },
    {
      "affiliations": [
        "Netherlands Organization for Applied Research, TNO, The Hague, Netherlands"
      ],
      "name": "Anjoeka Pronk"
    },
    {
      "affiliations": [
        "Department of Non-Communicable Diseases and Environment, Instituto de Salud Global Barcelona, Barcelona, Catalunya, Spain",
        "Pompeu Fabra University, Barcelona, Spain",
        "CIBER Epidemiología y Salud Publica (CIBERESP), Madrid, Spain, Madrid, Community of Madrid, Spain",
        "IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"
      ],
      "name": "Manolis Kogevinas"
    }
  ],
  "title": "Exposome project for health and occupational research night shift cohort (EPHOR-NIGHT): a unique resource to advance research on night shift work and chronic disease",
  "uid": "5b9d2e3c-f513-5cf8-8101-303ff1c26b50"
}