{
  "abstract": "Objective To explore the symptom experiences and self-management strategies of patients with chemotherapy-induced hand-foot syndrome (HFS), and to identify approaches for improving symptom control and quality of life.Design A qualitative study using semi-structured interviews and thematic analysis.Setting We conducted this study in the oncology inpatient ward of a tertiary hospital in Shanghai, China.Participants We used a purposive sampling approach to recruit 25 inpatients with chemotherapy-induced HFS from July 2022 to March 2024. The interviews were audio-recorded and transcribed verbatim. We employed an adapted version of Colaizzi’s qualitative analysis approach to examine the data.Results 25 patients (mean age 58 years; 56% male) with grade I–III chemotherapy-induced HFS were interviewed. Four inter-related themes emerged.(1) Symptom experience: pain, numbness and burning sensations disturbed sleep; visible peeling and hyper-pigmentation triggered embarrassment and self-consciousness.(2) Emotional responses: most participants accepted symptoms as ‘part of treatment’, yet persistent anxiety about progression and guilt over becoming a family burden were common.(3) Social impact: patients avoided outdoor activities, stopped caring for grandchildren and reported lost income because ‘hands can’t touch cold or rough items’.(4) Future expectations: participants wanted pictorial self-care guides, a nurse hotline after discharge and earlier introduction of pain-relief strategies. All expressed frustration at ‘no-one to ask’ once home.Conclusions Chemotherapy-induced HFS imposes a considerable multidimensional burden. Tailored, patient-centred interventions that integrate education, psychological support and family involvement are essential to improve symptom management and overall well-being. Future work should develop and test sustainable, long-term support strategies in broader populations.Scientific and clinical significance This study provides the first qualitative evidence base for understanding and managing chemotherapy-induced HFS in Chinese patients, informing nurse-led interventions, patient-reported outcome development and national supportive-care policy.",
  "authors": [
    {
      "affiliations": [
        "Department of Nursing, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China",
        "Department of Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China"
      ],
      "name": "Jie Zhang"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, The First Affiliated Hospital of Naval Medical University/Changhai Hospital, Naval Medical University, Shanghai, China",
        "National Key Laboratory of Immunity and Inflammation, Changhai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University/Changhai Hospital, Naval Medical University, Shanghai, China"
      ],
      "name": "Lei Huang"
    },
    {
      "affiliations": [
        "Department of Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China"
      ],
      "name": "Qianyun He"
    },
    {
      "affiliations": [
        "Department of Nursing, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China",
        "Department of Outpatient, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Xueqin Deng"
    },
    {
      "affiliations": [
        "Department of Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China"
      ],
      "name": "WenQi Xi"
    },
    {
      "affiliations": [
        "Department of Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China"
      ],
      "name": "Mei Wang"
    }
  ],
  "title": "Chemotherapy-induced hand-foot syndrome among Chinese inpatients: a qualitative descriptive study in Shanghai",
  "uid": "19783cd5-13c8-57f1-8898-6abd5382ffc2"
}