{
  "abstract": "Objective To investigate the relationship between a quality of life (QOL) score and clinical parameters in patients with hypertrophic cardiomyopathy (HCM).Design A multicentre cross-sectional study.Setting We analysed data from the Searching for Atrial Fibrillation and Early Recruitment of Heart Failure in HCM registry, collected between 2018 and 2023.Participants Patients with HCM (n=499) aged ≥18 years from 12 institutions (Shizuoka Prefecture, Japan) were consecutively enrolled.Outcome measures Clinical parameters, along with data from a short form of the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), were collected. The association between each clinical parameter and the KCCQ-12 score was analysed. Clinical parameters with a significant univariable association (p<0.05) were used in a multiple regression model to investigate independent clinical parameters associated with the KCCQ-12 score. The coefficients and relative importance of each parameter included in the multiple regression model were also evaluated.Results In the univariable analysis, KCCQ-12 scores exhibited significant associations with 21 clinical parameters, including sex, left ventricular morphology and the Pittsburgh Sleep Quality Index (PSQI). The multiple regression model with 12 parameters that had a significant univariable association exhibited an adjusted R 2 of 0.48. In this model, the PSQI (standardised coefficient −0.39; p<0.001), history of sustained ventricular tachycardia or fibrillation, history of atrial fibrillation (−0.23; p<0.001), female sex (−0.19; p=0.035), systolic blood pressure (0.17; p=0.040), lateral E/e prime (−0.17; p=0.049) and A wave (−0.14, p=0.049) were independently associated with the KCCQ-12 score with high relative importance.Conclusions In patients with HCM, we investigated the association between the KCCQ-12 score and various clinical parameters. PSQI, as well as known heart failure-related clinical parameters, was significantly associated with the KCCQ-12 score. Visualising the associations of various clinical parameters with the KCCQ-12 score will help physicians to consider factors linked to the decline in QOL in patients with HCM.",
  "authors": [
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Masao Saotome"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan",
        "Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York, USA"
      ],
      "name": "Keitaro Akita"
    },
    {
      "affiliations": [
        "Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"
      ],
      "name": "Shigetaka Kageyama"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Sayumi Suzuki"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Kazuto Ohno"
    },
    {
      "affiliations": [
        "Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"
      ],
      "name": "Masamitsu Kamakura"
    },
    {
      "affiliations": [
        "Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"
      ],
      "name": "Ryuzo Nawada"
    },
    {
      "affiliations": [
        "Takanaka Clinic, Hamamatsu, Japan"
      ],
      "name": "Chiei Takanaka"
    },
    {
      "affiliations": [
        "Department of Cardiology, Seirei Mikatahara General Hospital, Hamamatsu, Japan"
      ],
      "name": "Yasushi Wakabayashi"
    },
    {
      "affiliations": [
        "Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan"
      ],
      "name": "Takahiro Kanda"
    },
    {
      "affiliations": [
        "Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan"
      ],
      "name": "Kei Tawarahara"
    },
    {
      "affiliations": [
        "Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan"
      ],
      "name": "Masahiro Muto"
    },
    {
      "affiliations": [
        "Department of Cardiology, Iwata City Hospital, Iwata, Japan"
      ],
      "name": "Masaki Matsunaga"
    },
    {
      "affiliations": [
        "Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan"
      ],
      "name": "Satoru Suwa"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Shizuoka General Hospital, Shizuoka, Japan"
      ],
      "name": "Yasuyo Takeuchi"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Shizuoka General Hospital, Shizuoka, Japan"
      ],
      "name": "Hiroki Sakamoto"
    },
    {
      "affiliations": [
        "Department of Cardiology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan"
      ],
      "name": "Hideki Saito"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, JA Shizuoka Kohseiren Enshu Hospital, Hamamatsu, Japan"
      ],
      "name": "Kazusa Hayashi"
    },
    {
      "affiliations": [
        "Department of Cardiology, Fujinomiya City General Hospital, Fujinomiya, Japan"
      ],
      "name": "Nobuyuki Wakahara"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Kyoko Unno"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Takenori Ikoma"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Ryota Sato"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Keisuke Iguchi"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Terumori Satoh"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Makoto Sano"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Atsushi Sakamoto"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Kenichiro Suwa"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Yoshihisa Naruse"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Hayato Ohtani"
    },
    {
      "affiliations": [
        "Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
      ],
      "name": "Yuichiro Maekawa"
    },
    {
      "affiliations": [],
      "name": "Searching for Atrial Fibrillation and Early Recruitment of Heart Failure in HCM (SAFER-HCM) Registry Investigators"
    }
  ],
  "title": "Associations between heart failure-related quality of life and clinical parameters in patients with hypertrophic cardiomyopathy: a cross-sectional analysis of data from a multicentre Japanese registry",
  "uid": "990ba19b-328f-50df-ac5b-89e33773e529"
}