{
  "abstract": "Introduction Deep vein thrombosis (DVT) in critically ill patients is often undetected. However, it is unclear whether ultrasound surveillance for early detection of DVT in high-risk medical-surgical intensive care unit (ICU) patients improves patients’ outcomes. The DETECT trial (Diagnosing deep-vein thrombosis early in critically ill patients) evaluates the effect of twice-weekly bilateral lower limb ultrasound compared to usual care on 90-day mortality of critically ill adult patients admitted to medical, surgical and trauma ICUs.Methods and analysis The DETECT trial is an international, parallel-group, open-label, randomised trial, which will recruit 1800 critically ill adults from over 14 hospitals in Saudi Arabia and Kuwait. Eligible patients will be allocated to twice-weekly bilateral lower limb ultrasound or usual care. The primary outcome is 90-day mortality. Secondary outcomes include lower limb proximal DVT, pulmonary embolism and clinically important bleeding. The first patient was enrolled on 21 March 2023. As of 8 April 2025, 711 patients have been enrolled from 14 centres in Saudi Arabia and Kuwait. The first interim analysis was conducted on 14 May 2025. We expect to complete recruitment by December 2026.Ethics and dissemination Institutional review boards (IRBs) of each participating institution approved the study. We plan to publish the results in peer-reviewed journals and present the findings at international critical care conferences.Trial registration number Clinicaltrials.gov: NCT05112705, registered on 9-11-2021.",
  "authors": [
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Yaseen M Arabi"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Farhan Alenezi"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"
      ],
      "name": "Fahad Al-Hameed"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Haifa Ibrahim al Humedi"
    },
    {
      "affiliations": [
        "Pulmonary & Critical Care Departments, Ministry of Health, madinah, Saudi Arabia"
      ],
      "name": "Ayman Kharaba"
    },
    {
      "affiliations": [
        "Health Research Center, Ministry of Defense Health Services, Riyadh, Saudi Arabia"
      ],
      "name": "Waleed Alhazzani"
    },
    {
      "affiliations": [
        "Emergency and Critical Care, Imam Abdulrahman Bin Faisal University King Fahd Hospital of the University, Al Khobar, Eastern Province, Saudi Arabia"
      ],
      "name": "Mohammed Saeed Saad Alshahrani"
    },
    {
      "affiliations": [
        "King Abdulaziz University Hospital, Jeddah, Saudi Arabia"
      ],
      "name": "Haifa Algethamy"
    },
    {
      "affiliations": [
        "King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"
      ],
      "name": "Khalid Maghrabi"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, Al-Ahsa, Saudi Arabia"
      ],
      "name": "Jamal Chalabi"
    },
    {
      "affiliations": [
        "Biostatistics and Bioinformatics Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"
      ],
      "name": "Husam I Ardah"
    },
    {
      "affiliations": [
        "Intensive Care Department, Armed Forces Hospital, Khamis Mushait, Southern Region, Saudi Arabia"
      ],
      "name": "Ali Mousa Alahmari"
    },
    {
      "affiliations": [
        "Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia"
      ],
      "name": "Rakan M AlQahtani"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia"
      ],
      "name": "Abdalmohsen A Ababtain"
    },
    {
      "affiliations": [
        "Department of Intensive Care, Prince Mohammed Bin Abdul Aziz Hospital, Riyadh, Riyadh Province, Saudi Arabia"
      ],
      "name": "Wadiah Alawi M Al-Filfil"
    },
    {
      "affiliations": [
        "Department of Anesthesia, Critical Care Medicine and Pain Medicine and Kuwait Extracorporeal Life Support Program, Al-Amiri Hospital, Ministry of Health, Kuwait City, Al Asimah, Kuwait"
      ],
      "name": "Abdulrahman A Al-Fares"
    },
    {
      "affiliations": [
        "Department of Anesthesia, Critical Care and Pain Medicine, Jaber Al-Ahmad Hospital, Kuwait City, Al Asimah Governate, Kuwait"
      ],
      "name": "Sarah Fadel Buabbas"
    },
    {
      "affiliations": [
        "King Abdullah International Medical Research Center, Riyadh, Riyadh Province, Saudi Arabia"
      ],
      "name": "Felwa bin Humaid"
    },
    {
      "affiliations": [
        "Medical Imaging Department, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"
      ],
      "name": "Mohammed J Brembali"
    },
    {
      "affiliations": [
        "King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"
      ],
      "name": "Marwa Amer"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Musharaf Sadat"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Abdullah Al Tamimi"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Amjad AlHumaidan"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Mohammed Alqahtani"
    },
    {
      "affiliations": [
        "Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia"
      ],
      "name": "Abdulaziz Al-Dawood"
    },
    {
      "affiliations": [],
      "name": "the Saudi Critical Care Trials Group"
    }
  ],
  "title": "Diagnosing deep vein thrombosis early in critically ill patients (DETECT) trial: a protocol for a randomised controlled trial",
  "uid": "48274b03-8add-58f0-86c9-57462ceef913"
}