{
  "abstract": "Objective Platelet and fresh frozen plasma (FFP) transfusions are routinely employed in the management of severe dengue. Previous research has indicated a potential link between ABO blood groups and susceptibility to dengue, with evidence suggesting that mosquito vector feeding preferences may be influenced by host blood type. These factors could potentially impact transfusion demands during outbreaks. This retrospective study aimed to investigate the relationship between ABO blood groups and transfusion requirements in patients with dengue.Design Retrospective study.Setting The study was conducted at a tertiary care hospital in Kerala.Methods Clinical and laboratory data were reviewed for 199 patients confirmed with dengue who received blood component transfusions and compared with two control groups: 200 randomly selected patients with dengue who did not require transfusions and 200 patients without dengue who required transfusions, over a period spanning January 2015 to March 2023.Results Among transfused dengue cases, blood groups O (41.71%), A (28.14%) and B (23.12%) were most prevalent; however, no statistically significant association was observed between ABO blood group and transfusion requirement. Furthermore, the total volumes of FFP and platelet transfusions did not differ significantly across ABO groups among patients with dengue. Notably, platelet transfusions were significantly more frequent in dengue cases (92.0%) compared with transfused patients without dengue (35.5%), whereas FFP transfusions were more common in non-dengue transfused cases (84.5%) than in patients with dengue (44.7%). Patients with dengue also received significantly higher mean volumes of both FFP and platelets.Conclusion Despite earlier reports linking ABO blood types to dengue susceptibility, this study found no significant association with transfusion requirements, warranting confirmation through larger multicentre studies.",
  "authors": [
    {
      "affiliations": [
        "Department of Biochemistry, Believers Church Medical College Hospital, Thiruvalla, Kerala, India",
        "Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Cleetus Cherupanakkal"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Anupa Jacob"
    },
    {
      "affiliations": [
        "Department of Public Health, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"
      ],
      "name": "Jeby Jose Olickal"
    },
    {
      "affiliations": [
        "Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Jabiya Eliza Varughese"
    },
    {
      "affiliations": [
        "Department of General Medicine, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Ani Thampi"
    },
    {
      "affiliations": [
        "Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India",
        "Department of Microbiology, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Anjali Anne Jacob"
    },
    {
      "affiliations": [
        "Department of Biochemistry, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Riju Mathew"
    },
    {
      "affiliations": [
        "Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Gayathri Jayaprasad"
    },
    {
      "affiliations": [
        "Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"
      ],
      "name": "Jisha Elsa Varghese"
    }
  ],
  "title": "Association between ABO blood group and blood component transfusion requirements in dengue infection: a retrospective study from a tertiary hospital in Kerala, India",
  "uid": "725be6f2-e4a7-547a-a19f-208dbc3e0b3f"
}