{
  "abstract": "Objectives This study aims to explore the associations of the neutrophil-to-lymphocyte ratio (NLR) and the systemic inflammatory response index (SIRI) with all-cause mortality among adults with nasal colonisation of Staphylococcus aureus (S. aureus).Design A cross-sectional study.Setting The National Health and Nutrition Examination Survey (2001–2004).Participants A total of 10 600 adults aged 18 years or older were included in this study, of whom 2805 were colonised with nasal S. aureus.Primary and secondary outcome measures All-cause mortality was considered as primary outcomes. Survey-weighted Cox proportional hazards models were applied to evaluate the associations of NLR and SIRI with all-cause mortality after adjustment for confounders. Predictive performance was assessed using time-dependent receiver operating characteristic (ROC) curves, and survival differences were illustrated by Kaplan-Meier (K-M) analysis. Restricted cubic spline (RCS) models further examined potential non-linear associations.Results During a median follow-up of 197 months, 595 deaths occurred. The fully adjusted Cox model showed that elevated NLR (1.87 (1.32, 2.65), p<0.001) and SIRI (1.88 (1.43, 2.48), p<0.001) were significantly associated with increased all-cause mortality risk. These associations were consistent across subgroup analyses by sex, age, education, race, family poverty income ratio, smoking, drinking, diabetes, cancer and long-term care. K-M curves showed significantly lower survival rates in high NLR and SIRI groups (p<0.0001). RCS analysis revealed non-linear relationships between NLR and SIRI, with all-cause mortality (p>0.05).Conclusions Elevated NLR and SIRI levels are positively associated with higher all-cause mortality risk among adult individuals with nasal S. aureus colonisation.",
  "authors": [
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Ju Zou"
    },
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Yuanyuan Xiao"
    },
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Biyue Tian"
    },
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Siyao Chen"
    },
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Anhua Wu"
    },
    {
      "affiliations": [
        "Department of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China",
        "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China"
      ],
      "name": "Chunhui Li"
    }
  ],
  "title": "Associations of NLR and SIRI with all-cause mortality among adults with nasal Staphylococcus aureus colonisation: a cross-sectional study of NHANES, 2001–2004",
  "uid": "6ba3e114-61b1-5aa9-8fbe-4ae618c5de83"
}