{
  "abstract": "Background We aimed to examine the associations of handgrip strength and walking pace with the risk of incident diabetes mellitus (DM) among people with HIV (PWH).Design A cohort study.Setting This study was conducted in Taizhou City Center for Disease Control and Prevention in Zhejiang Province, mainland China.Participants A total of 1916 participants (mean age 43.3±14.2 years, 77.7% male) without diagnosed or unknown DM at baseline from the Comparative HIV and Aging Research in Taizhou cohort were included.Outcome measures The primary outcome was incident DM, defined by fasting glucose >7.0 mmol/L, HbA1c concentration >6.5% or diagnosed with DM by a doctor during the period of follow-up.Results During a mean follow-up of 3.2 years, 184 incident DM cases were identified. Overall, there was a significant inverse association between both handgrip strength and walking pace with the risk of incident DM in PWH. Compared with participants with lower handgrip strength (<32.1 and <20.3 kg for males and females) or slower walking pace (<2.1 miles/hour), those with higher handgrip strength (≥32.1 and ≥20.3 kg for males and females) or faster walking pace (≥2.1 miles/hour) had a lower risk of incident DM, the adjusted HR (aHRs) (95% CI were 0.60 (0.42 to 0.85) and 0.59 (0.42 to 0.83), respectively. A higher handgrip strength and a faster walking pace were responsible for 38.0% and 39.7% of DM cases, respectively. Moreover, the lowest risk of incident DM was observed in participants with both higher handgrip strength and faster walking pace (aHR, 0.44; 95% CI 0.25 to 0.76).Conclusion Higher handgrip strength or faster walking pace was significantly associated with a reduced risk of incident DM among PWH.",
  "authors": [
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Qiguo Meng"
    },
    {
      "affiliations": [
        "Jiaojiang Center for Disease Control and Prevention, Taizhou, Zhejiang, China"
      ],
      "name": "Congcong Guo"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Yali Xie"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Haijun Zhang"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Xiaoxiao Chen"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Shanling Wang"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Tingting Hua"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Yating Wang"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Tingting Wang"
    },
    {
      "affiliations": [
        "Taizhou Municipal Center for Disease Control and Prevention, Taizhou Municipal Institute of Health Supervision, Taizhou, Zhejiang, China"
      ],
      "name": "Haijiang Lin"
    },
    {
      "affiliations": [
        "Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China"
      ],
      "name": "Na He"
    }
  ],
  "title": "Handgrip strength and walking pace negatively impact the incidents of diabetes mellitus among people with HIV: a prospective cohort study in China",
  "uid": "ca86d332-ca9d-52c2-928b-ca88bb67cb5f"
}