{
  "abstract": "Background Allergic rhinitis (AR) is a common chronic inflammatory condition that significantly impairs quality of life (QoL) through symptoms such as nasal congestion, rhinorrhoea, sneezing and itching. Conventional treatments often show limitations, prompting interest in complementary therapies like herbal medicine (HM). HM is widely used in East Asian countries and has demonstrated potential in modulating immune responses and reducing AR symptoms. In Korea, a government pilot project expanded in 2024 to include AR under limited insurance coverage for HM, highlighting the need for robust clinical evidence on its safety and effectiveness.Methods and analysis This study is a multicentre, prospective registry conducted in 21 Korean Medicine (KM) clinics across Republic of Korea. The registry systematically collects real-world data on HM treatments for AR, focusing on patient demographics, treatment patterns and clinical outcomes. Participants meeting predefined criteria will receive HM or other KM therapies as part of routine care. Data will be collected bi-weekly for the first 4 weeks, with additional follow-ups at 6 and 12 months. Primary outcomes include changes in Total Nasal Symptom Score, QoL scores and safety evaluations, analysed using descriptive and inferential statistical methods.Ethics and dissemination This study was approved by the Institutional Review Board of Kyung Hee University on 11 December 2024 (Approval No. KHSIRB-24–631). The study findings will be published in peer-reviewed journals and presented at academic conferences.Trial registration number KCT0010172.",
  "authors": [
    {
      "affiliations": [
        "KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Soo-Dam Kim"
    },
    {
      "affiliations": [
        "KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Boram Lee"
    },
    {
      "affiliations": [
        "Department of Korean Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Korean Medicine, Seoul, Korea (the Republic of)"
      ],
      "name": "Gyu Tae Chang"
    },
    {
      "affiliations": [
        "HAMSOA Pharmaceutical, Seoul, Korea (the Republic of)"
      ],
      "name": "Eun Kyoung Lee"
    },
    {
      "affiliations": [
        "HAMSOA Korean Medicine Clinics, Seoul, Korea (the Republic of)"
      ],
      "name": "Hamsoa Clinics KM Doctors Group"
    },
    {
      "affiliations": [
        "KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Mi Mi Ko"
    },
    {
      "affiliations": [
        "KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Anna Kim"
    },
    {
      "affiliations": [
        "KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Young Eun Kim"
    },
    {
      "affiliations": [
        "KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Su-Min Seo"
    },
    {
      "affiliations": [
        "KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Daejeon, Korea (the Republic of)"
      ],
      "name": "Mi Ju Son"
    }
  ],
  "title": "Cohort of allergic rhinitis evaluation of effectiveness and safety of herbal medicine (CARE-HM): protocol for the clinic-based multicentre Korean Medicine Registry",
  "uid": "f7d693e5-a428-5406-8a04-8be2ba34b3dd"
}