{
  "abstract": "Introduction Vaccination has been an effective public health intervention for immunising individuals against many common communicable and non-communicable diseases. However, there is limited information on the efficacy of vaccination among patients undergoing dialysis or patients with chronic kidney disease (CKD). The objective of this review is to assess the effectiveness of vaccination within dialysis and CKD patient populations.Methods and analysis This will be a systematic review of studies assessing the effectiveness of vaccination among CKD and dialysis patients. Relevant studies will be identified using MEDLINE, Embase, Scopus and Cochrane Library. All searches will be conducted from database inception to October 2025. Only observational studies such as cohort, prospective, retrospective and cross-sectional studies will be included. Data pertaining to patient outcomes and study design will be extracted. A narrative synthesis will be conducted as well as a meta-analysis if data permitting this analysis is extracted from included studies.Ethics and dissemination Since data collection will be conducted by examining existing studies, no ethical approval or consent will be required. The results of this review will be published in a peer-reviewed journal as well as presented at seminars, conferences and symposiums.Trial registration number This review protocol has been registered in International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42025648534.",
  "authors": [
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"
      ],
      "name": "Marisha Karim"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada",
        "McMaster University Faculty of Science, Hamilton, Ontario, Canada"
      ],
      "name": "Benjamin Milone"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"
      ],
      "name": "Amos Buh"
    },
    {
      "affiliations": [
        "Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"
      ],
      "name": "Nicole Wisener"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"
      ],
      "name": "Cerine Benomar"
    },
    {
      "affiliations": [
        "Medical Daycare Unit, Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada"
      ],
      "name": "Phalone Mei Nsen"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada",
        "Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada",
        "Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"
      ],
      "name": "Ayub Akbari"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada",
        "Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada",
        "Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada",
        "Division Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"
      ],
      "name": "Pierre A Brown"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada",
        "Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada",
        "Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"
      ],
      "name": "Gregory L Hundemer"
    },
    {
      "affiliations": [
        "The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada",
        "Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada",
        "Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"
      ],
      "name": "Manish Sood"
    }
  ],
  "title": "Effectiveness of vaccination in patients undergoing dialysis or patients with chronic kidney disease: a systematic review protocol",
  "uid": "3390d442-0754-5cef-bdc6-b9c48633dc07"
}