{
  "abstract": "Introduction Head and neck cancer (HNC) affects the mouth, throat, salivary glands, voice box, nose or sinuses. Every year, over 12 000 people in the UK are diagnosed with HNC. Neck dissection is a key, surgical component of patient care. However, many people experience postoperative restriction in shoulder and neck movements, pain, fatigue and low mood, with only half ever returning to work.Methods and analysis Getting Recovery Right After Neck Dissection (GRRAND) is a two-arm, multicentre, pragmatic randomised controlled trial. The trial aims to compare clinical and cost-effectiveness of a personalised physiotherapy programme (GRRAND programme) versus usual practice, National Health Service (NHS), postdischarge care.The planned sample size is 390 participants. Participants will be recruited from across UK sites and followed up for 12 months. The primary outcome is the shoulder pain and disability index at 12 months. Economic evaluation will be conducted from a healthcare system and personal social services perspective. Secondary outcome data, including pain, function, health-related quality of life, mental well-being, health resource use and adverse events, will be collected at 6 weeks, 3, 6 and 12 months, with exercise adherence at 6 weeks. A process evaluation will determine how GRRAND is implemented, delivered and received across clinical settings, exploring what works, for whom and under what conditions. Analysis will be on an intention-to-treat basis and reported inline with the Consolidated Standards of Reporting Trials statement.Ethics and dissemination The trial was approved by the London-Brent Research Ethics Committee (ref: 24/LO/0722) on 15 October 2024. Trial results will be disseminated via peer-reviewed publications, presentations at national and international conferences, in lay summaries and social media. This protocol adheres to the recommended Standard Protocol Items: Recommendations for Interventional Trials checklist.Trial registration number ISRCTN13855775.",
  "authors": [
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Chrissy Evans"
    },
    {
      "affiliations": [
        "Department of Health and Community Sciences, University of Exeter, Exeter, UK"
      ],
      "name": "Leanne Greene"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Anower Hossain"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Pritpal Klear"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Mariam Ratna"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Helen Bradley"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Ranjit Lall"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Hema Mistry"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Seyran Naghdi"
    },
    {
      "affiliations": [
        "Oxford University Hospitals NHS Foundation Trust, Oxford, UK"
      ],
      "name": "Marco Reategui"
    },
    {
      "affiliations": [
        "Oxford University Hospitals NHS Foundation Trust, Oxford, UK"
      ],
      "name": "Tony Stevens"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"
      ],
      "name": "Julie Bruce"
    },
    {
      "affiliations": [
        "Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK"
      ],
      "name": "Ruth Price"
    },
    {
      "affiliations": [
        "Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK",
        "University of Liverpool Faculty of Health and Life Sciences, Liverpool, UK"
      ],
      "name": "Andrew Schache"
    },
    {
      "affiliations": [
        "Department of Health and Community Sciences, University of Exeter, Exeter, UK"
      ],
      "name": "Sarah Gerard Dean"
    },
    {
      "affiliations": [
        "College of Medicine and Health, University of Exeter, Exeter, UK"
      ],
      "name": "Sarah Elizabeth Lamb"
    },
    {
      "affiliations": [
        "Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK",
        "Institute for Applied & Translational Technologies in Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"
      ],
      "name": "Toby Smith"
    },
    {
      "affiliations": [
        "Oxford University Hospitals NHS Foundation Trust, Oxford, UK",
        "Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"
      ],
      "name": "Stuart C Winter"
    }
  ],
  "title": "Getting recovery right after neck dissection for head and neck cancer (GRRAND): trial protocol for a multicentre, pragmatic randomised controlled trial with health economic evaluation and process evaluation",
  "uid": "e321df67-479d-5802-a619-1de875e51114"
}