{
  "abstract": "Objective Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) entails substantial morbidity and mortality, yet no epidemiologic evidence exists on its outcomes in Mexico. This study assessed national hospitalisations (2005–2022) and mortality (2000–2022) related to AAV using data from the General Board of Health Information.Design Retrospective, population-based time-trend analysis on administrative health data.Setting Mexico’s national hospital discharge and mortality registries, covering 1 January 2000 through 31 December 2022.Participants All individuals aged ≥ 15 years with a primary or secondary International Classification of Diseases, 10th revision, diagnosis of AAV recorded during hospitalisation or on death certificates nationwide.Outcome measures The study’s primary outcomes were the age-standardised hospitalisation and mortality rates for AAV (expressed per 100 000 population, overall and by sex), with temporal trends in both rates quantified using Joinpoint regression to calculate annual percent change (APC) and average APC (AAPC).Results We identified 2804 hospitalisations and 599 deaths. Females accounted for 49.7% of hospitalisations, while males represented 48.7% of deaths. Although the overall age-standardised hospitalisation rate (ASHR) and mortality rate (ASMR) AAPCs were not statistically significant, relevant trends emerged. From 2010 to 2022, ASHR declined significantly (APC: −5.2%; 95% CI −9.7, –0.5; p=0.03), whereas mortality rates remained stable from 2000 to 2022 (AAPC: +3%; 95% CI −4.6, 11.3; p=0.45). Nevertheless, mortality increased among males (APC: +6.4%; 95% CI 0.9, 12.2; p=0.02) and individuals over 45 years (APC: +8.6%; 95% CI 1.7, 16.0; p=0.02) from 2008 onwards.Conclusions Overall, these findings indicate no major changes in national rates but reveal a decline in hospitalisations since 2010 and a rise in mortality for specific subgroups since 2008. Targeted interventions, particularly for older adults and men, appear warranted to address this evolving disease burden. Future research should explore underlying risk factors and evaluate tailored strategies to improve clinical outcomes in AAV across Mexico.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico"
      ],
      "name": "Ivet Etchegaray-Morales"
    },
    {
      "affiliations": [
        "Systemic Rheumatic and Autoimmune Diseases Research Unit, Instituto Mexicano del Seguro Social, Puebla, Mexico",
        "Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico"
      ],
      "name": "Claudia Mendoza-Pinto"
    },
    {
      "affiliations": [
        "Systemic Rheumatic and Autoimmune Diseases Research Unit, Instituto Mexicano del Seguro Social, Puebla, Mexico",
        "Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico"
      ],
      "name": "Susana Barrera-Hernández"
    },
    {
      "affiliations": [
        "Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico"
      ],
      "name": "Yolanda Martina Martinez-Barragan"
    },
    {
      "affiliations": [
        "Systemic Rheumatic and Autoimmune Diseases Research Unit, Instituto Mexicano del Seguro Social, Puebla, Mexico",
        "Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico"
      ],
      "name": "Pamela Munguía-Realpozo"
    },
    {
      "affiliations": [
        "Rheumatology Unit, Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico"
      ],
      "name": "Ingris Pelaez-Ballestas"
    },
    {
      "affiliations": [
        "Department of Biomedicine, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico"
      ],
      "name": "Roberto Berra-Romani"
    },
    {
      "affiliations": [
        "Systemic Rheumatic and Autoimmune Diseases Research Unit, Instituto Mexicano del Seguro Social, Puebla, Mexico"
      ],
      "name": "Edith Ramírez-Lara"
    },
    {
      "affiliations": [
        "Research Coordination, Delegation of Puebla, Instituto Mexicano del Seguro Social, Mexico City, Mexico"
      ],
      "name": "Jorge Ayón-Aguilar"
    },
    {
      "affiliations": [
        "Research Coordination, Delegation of Puebla, Instituto Mexicano del Seguro Social, Mexico City, Mexico"
      ],
      "name": "Socorro Méndez-Martínez"
    }
  ],
  "title": "Hospitalisation and mortality trends in ANCA-associated vasculitis in Mexico: results from a nationwide retrospective registry analysis",
  "uid": "5deaa1fc-1d40-592e-afed-4239ac11278e"
}