{
  "abstract": "Objective The waist-hip ratio (WHR) and waist-height ratio (WHtR) are associated with arterial stiffness (AS), yet there is limited research on this topic in patients with type 2 diabetes mellitus (T2DM). This study aims to investigate the relationship between WHR, WHtR and AS in patients with T2DM.Setting This cross-sectional study used data from patients with T2DM enrolled in the Metabolic Disease Management Center (MMC) at Changde Hospital, Xiangya School of Medicine, Central South University between May 2020 and October 2023.Participants A total of 3201 patients were collected, and after applying the exclusion criteria, data from 3006 patients were finally analysed.Primary outcomes The primary outcome of AS was assessed using brachial-ankle pulse wave velocity (baPWV).Results After adjusting for gender and age, there was an increasing trend in baPWV across the quartiles of WHR and WHtR. In the multivariate regression analysis adjusting for confounding factors, it was observed that for each one-unit increase in the WHR z-score, baPWV increased by 18.1 cm/s (95% CI: 7.8 to 28.4). Similarly, for each one-unit increase in the WHtR z-score, baPWV increased by 28.6 cm/s (95% CI: 16.6 to 40.6). In the multivariate logistic regression analysis, after fully adjusting for confounding factors, it was found that for every one-unit increase in the WHR z-score, the OR for elevated baPWV was 1.2 (95% CI: 1.1 to 1.4). Similarly, for every one-unit increase in the WHtR z-score, the OR for elevated baPWV was 1.3 (95% CI: 1.1 to 1.5). According to the generalised additive model, we found that WHR and WHtR were positively correlated with baPWV and elevated baPWV. Subgroup analysis revealed that elevated WHR and WHtR are significant predictors of AS, with this association being substantially amplified by poor glycaemic control (glycated haemoglobin ≥7%).Conclusion In Chinese patients with T2DM, both WHR and WHtR are positively and independently associated with baPWV and the presence of elevated baPWV.",
  "authors": [
    {
      "affiliations": [
        "Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Jian Luo"
    },
    {
      "affiliations": [
        "Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Haifeng Zhou"
    },
    {
      "affiliations": [
        "Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Fang Yu"
    },
    {
      "affiliations": [
        "Department of Science and Education, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Quan Zhou"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Xueyan Wu"
    },
    {
      "affiliations": [
        "Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Qin Liu"
    },
    {
      "affiliations": [
        "Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China"
      ],
      "name": "Shenglian Gan"
    }
  ],
  "title": "Association between anthropometric indices and early arterial stiffness in patients with type 2 diabetes in China: a cross-sectional study",
  "uid": "06016240-56df-552b-a745-00e3a9d096f0"
}