{
  "abstract": "Introduction Most clinical practice guidelines (CPGs) for assessing and managing people’s chronic pain focus on specific pain conditions, body sites or life course stages. This creates complexity for clinicians making care choices in the absence of a diagnosis and/or where a person experiences more than one pain condition. Specific to this context is the ICD-11 classification of chronic primary pain where an experience of pain cannot be better accounted for by another condition. CPGs for chronic primary pain, agnostic to condition or body part, may support clinicians towards best pain care since many of the principles of person-centred chronic pain care are transdiagnostic. The two aims of this systematic review are to (1) identify and appraise CPGs for chronic primary pain, relevant across the life course and (2) map the CPG content against a pain care priority framework to evaluate the extent to which the CPG content aligns with the priorities of people with lived chronic pain experience.Methods and analysis We will systematically search nine scholarly databases, the Epistemonikos database and international and national guidelines clearinghouses. CPGs published within 2015–2025, in any language, that offer recommendations about assessment and/or management of chronic primary pain for people of any age, excluding hospitalised inpatients or institutionalised populations, will be included. Pairs of reviewers will independently screen citations for eligibility and appraise CPG quality and implementation potential using the Appraisal of Guidelines for Research and Evaluation (AGREE)-II and the AGREE-Recommendations Excellence tools, respectively. Data extraction will include the citation and scope characteristics of each CPG, methods used to develop recommendations, verbatim recommendations, guiding principles or practice information and narrative excerpts related to the GRADE Evidence-to-Decision (EtD) considerations (or equivalent). We will use the PROGRESS-PLUS framework as a checklist to identify whether determinants of health equity were considered by guideline developers. CPG recommendations will be organised according to common topics and categorised in a matrix according to strength and direction. Qualitative content analysis will be used to synthesise excerpts relating to GRADE EtD considerations (or equivalent), and we will map extracted data against an established chronic pain care priority framework to determine the extent to which the CPGs align with values and preferences of people with lived experience. Interpretation will be informed by an interdisciplinary Advisory Group, including lived experience partners.Ethics and dissemination Ethical approval is not required for this systematic review. Results will be disseminated through publication in an open-access peer-reviewed journal, through professional societies, and integrated into education curricula and public-facing resources. Reporting will be consistent with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.PROSPERO registration number CRD420251000482.",
  "authors": [
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Andrew M Briggs"
    },
    {
      "affiliations": [
        "Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa",
        "Independent Clinical Epidemiologist, Cape Town, South Africa"
      ],
      "name": "Nandi Siegfried"
    },
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Robert Waller"
    },
    {
      "affiliations": [
        "Department of Health Sciences, Brunel University London - Uxbridge Campus, London, UK"
      ],
      "name": "Neil E O’Connell"
    },
    {
      "affiliations": [
        "Ian Potter Library, Alfred Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Lorena Romero"
    },
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Nardia-Rose Klem"
    },
    {
      "affiliations": [
        "Department of Health Sciences, Brunel University London - Uxbridge Campus, London, UK"
      ],
      "name": "Paapa Kwesi Ampiah"
    },
    {
      "affiliations": [
        "Independent Lived Experience Partner, Fraser, Colorado, USA"
      ],
      "name": "Joletta L Belton"
    },
    {
      "affiliations": [
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Fiona M Blyth"
    },
    {
      "affiliations": [
        "Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Simone De Morgan"
    },
    {
      "affiliations": [
        "School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia",
        "The University of Newcastle Hunter Medical Research Institute, New Lambton, New South Wales, Australia"
      ],
      "name": "Susan M Lord"
    },
    {
      "affiliations": [
        "Pain Management Research Institute, The Kolling Institute, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Michael Nicholas"
    },
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Peter B O’Sullivan"
    },
    {
      "affiliations": [
        "Independent Lived Experience Partner, Lalitpur, Nepal"
      ],
      "name": "Asim Shakya"
    },
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Anne J Smith, Dr"
    },
    {
      "affiliations": [
        "Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia"
      ],
      "name": "Helen Slater"
    }
  ],
  "title": "Clinical practice guidelines for the care of people experiencing chronic primary pain: protocol for a systematic review with interpretation against an established chronic pain care priority framework",
  "uid": "efdb4280-176b-5d3a-99a3-4d137f048c22"
}