{
  "abstract": "Introduction The Cardiometabolic function in Offspring, Mother and Placenta after Assisted Reproductive Technology (COMPART) study is a prospective cohort study aiming to explore health outcomes in mothers and children following assisted reproductive technology (ART), with a particular focus on frozen embryo transfer (FET) versus fresh embryo transfer (fresh-ET). The increasing prevalence of ART and FET emphasises the need to assess potential health risks associated with the procedures, both in pregnancy, such as pre-eclampsia and large for gestational age offspring, and in the children, such as obesity and cardiometabolic dysfunction.Methods and analysis The cohort will include 600 pregnant women, their potential partner and their offspring in a 1:1:1 ratio of pregnancies achieved after ART with FET, ART with fresh-ET and women who conceived naturally. The study will involve extensive data collection from electronic medical records; parental questionnaires; biochemical, genetic and epigenetic analyses in blood, urine and placental tissue; and medical imaging (fetal ultrasound and PEA POD scan) and clinical examinations. Outcomes are grouped into six work packages (WPs) related to fetal growth (WP1), pregnancy (WP2), placenta (WP3), offspring (WP4), genetics (WP5) and epigenetics (WP6).Ethics and dissemination The COMPART study aims to provide valuable insights into the impact of ART and FET on maternal and offspring health and the underlying mechanisms responsible. The study seeks to advance reproductive medicine, shape clinical practice and guidelines and ultimately ensure maternal-fetal health following ART. The study has been approved by the Danish Ethics Committee (H-23071266; February 2024).Trial registration number NCT06334003",
  "authors": [
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark",
        "Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Herlev Hospital, Copenhagen, Denmark"
      ],
      "name": "Anna Sophie Lebech Kjaer"
    },
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark",
        "Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Herlev Hospital, Copenhagen, Denmark"
      ],
      "name": "Maria Linander Vestager"
    },
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark",
        "Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Herlev Hospital, Copenhagen, Denmark"
      ],
      "name": "Elisabeth Blixenkrone-Møller"
    },
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"
      ],
      "name": "Louise Laub Asserhøj"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Herlev Hospital, Copenhagen, Denmark",
        "Department of Diabetes Care, Steno Diabetes Center Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Julie Tonsgaard Kloppenborg"
    },
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Kristine Løssl"
    },
    {
      "affiliations": [
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark",
        "The Fetal Medicine Unit, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"
      ],
      "name": "Charlotte K Ekelund"
    },
    {
      "affiliations": [
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark",
        "Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"
      ],
      "name": "Line Rode"
    },
    {
      "affiliations": [
        "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Line Hjort"
    },
    {
      "affiliations": [
        "Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Eva R Hoffmann"
    },
    {
      "affiliations": [
        "Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Julie Lyng Forman"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Herlev Hospital, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Rikke Beck Jensen"
    },
    {
      "affiliations": [
        "The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Anja Pinborg"
    }
  ],
  "title": "Cardiometabolic function in Offspring, Mother and Placenta after Assisted Reproductive Technology (COMPART): a prospective cohort study",
  "uid": "5e74d307-dc46-586e-970b-2c3905a260b9"
}