{
  "abstract": "Introduction Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide, associated with significant morbidity, mortality and healthcare utilisation. AF rhythm control strategies demonstrate attrition with time. A number of modifiable AF risk factors contribute to an atrial cardiomyopathy culminating in incident AF but importantly also recurrence. We propose that a novel multidisciplinary lifestyle intervention (Super Rehab, SR) may improve symptoms and AF burden.Methods and analysis This is a single-centre, randomised controlled study. Patients aged ≥18 years with a body mass index ≥27 kg/m 2 with paroxysmal or persistent AF will be randomised 1:1 to National Health Service (NHS) usual care (UC) or to SR (together with NHS UC). SR incorporates high-intensity exercise, personalised dietary advice and AF risk factor modification. SR will be undertaken over 12 months. In addition to baseline assessments, follow-up assessments will occur at the 6, 12 and 15-month time points. The primary outcome will be the difference in AF symptom burden at 12 months between groups. Secondary outcomes include AF burden (assessed by an implantable cardiac monitor), changes to cardiac structure and function and computed tomography-based assessment of epicardial adipose tissue.Ethics and dissemination Ethics approval was granted by London-Chelsea Research Ethics Committee (reference: 22/LO/0479 22/08/2022). All participants will provide written informed consent prior to enrolment. Study findings will be disseminated via presentations to relevant stakeholders, national and international conferences and open-access peer-reviewed research publications. A summary will also be communicated to the participants.Trial registration number ClinicalTrials.gov ID NCT05596175.",
  "authors": [
    {
      "affiliations": [
        "Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK",
        "Department for Health, University of Bath, Bath, UK"
      ],
      "name": "David Murphy"
    },
    {
      "affiliations": [
        "Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK",
        "Department for Health, University of Bath, Bath, UK"
      ],
      "name": "John Graby"
    },
    {
      "affiliations": [
        "Department of Mathematics, University of Bath, Bath, UK"
      ],
      "name": "Theresa Smith"
    },
    {
      "affiliations": [
        "Department for Health, University of Bath, Bath, UK"
      ],
      "name": "Oliver Peacock"
    },
    {
      "affiliations": [
        "Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK",
        "Department for Health, University of Bath, Bath, UK"
      ],
      "name": "Joanna Abramik"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Oxford, Oxford, UK"
      ],
      "name": "Charalambos Antoniades"
    },
    {
      "affiliations": [
        "Department for Health, University of Bath, Bath, UK",
        "Radiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK"
      ],
      "name": "Jonathan Carl Luis Rodrigues"
    },
    {
      "affiliations": [
        "Department for Health, University of Bath, Bath, UK"
      ],
      "name": "Dylan Thompson"
    },
    {
      "affiliations": [
        "Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK"
      ],
      "name": "Ali Khavandi"
    }
  ],
  "title": "Effectiveness of a novel intervention (Super Rehab) in overweight patients with atrial fibrillation (SuRe AF): protocol for a randomised controlled trial",
  "uid": "3c3600fe-47fe-50d3-9d10-90621eb48e20"
}