{
  "abstract": "Introduction Intracranial atherosclerosis is the main cause of stroke globally, with acute large vessel occlusive (LVO) stroke being a predominant contributor to stroke-related mortality. In recent years, aspiration thrombectomy (AT) has emerged as a novel therapeutic method for treating acute LVO stroke. The purpose of this study aims to investigate the safety and efficacy of AT alone or combined with stent retriever thrombectomy (SRT) in the treatment of acute LVO strokeMethods and analysis This is a multicentre and observational real-world study involving patients diagnosed with acute LVO stroke. Participants will be treated with AT alone or combined with SRT. According to the actual annual number of embolectomy in the sub-centre and the research years, the sample size of this study is estimated to be 400 patients, of which 300 patients of anterior circulation lesions and 100 patients of posterior circulation lesions are planned to be recruited, being considered that the incidence of posterior circulation is about 20–25%. Clinical data, including baseline characteristics, intraoperative details, postoperative outcomes and follow-up results, will be systematically collected using an Electronic Data Capture system over a follow-up period of 3 months. The primary efficacy endpoint is the rate of excellent functional outcome (modified Rankin Scale score range 0–3) after 90 days, and the successful recanalisation confirmed by digital subtraction angiography. The primary safety outcome is symptomatic intracranial haemorrhage within 48 hours (National Institutes of Health Stroke Scale score increase ≥4). This study will provide us with powerful guidance for the treatment of acute LVO stroke with different aetiologies.Ethics and dissemination This study protocol was approved by the Ethics Committee on Human Experimentation at Shandong Provincial Hospital Affiliated to Shandong First Medical University (approval number: SWYX:2022–1025). All the participating sites have received the ethics approval. The outcomes will be disseminated through national and international presentations and peer-reviewed publications.Trial registration number ChiCTR2200065172.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"
      ],
      "name": "Peng Yan"
    },
    {
      "affiliations": [
        "Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"
      ],
      "name": "Maoyu Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Liaocheng Third People's Hospital, Liaocheng, China"
      ],
      "name": "Lei Yang"
    },
    {
      "affiliations": [
        "Department of Neurology, Liaocheng Third People's Hospital, Liaocheng, China"
      ],
      "name": "Cunfeng Song"
    },
    {
      "affiliations": [
        "Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, Chongqing, China"
      ],
      "name": "Shudong Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Shengli Oilfield Central Hospital, Dongying, Shandong, China"
      ],
      "name": "Xiaohui Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, Chongqing, China"
      ],
      "name": "Shengli Chen"
    },
    {
      "affiliations": [
        "The Second Department of Neurology, Qingdao Central Hospital of University of Health and Rehabilitation Sciences, Qingdao, Shandong, China"
      ],
      "name": "Haicheng Yuan"
    },
    {
      "affiliations": [
        "Department of Neurology, Heze Municipal Hospital, Heze, Shandong, China"
      ],
      "name": "Kai Li"
    },
    {
      "affiliations": [
        "Department of Emergency Stroke, Affiliated Hospital of Jining Medical University, Jining, Shandong, China"
      ],
      "name": "Qiang Guo"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, Handan First Hospital, Handan, Hebei, China"
      ],
      "name": "Hui Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Xishan People’s Hospital of Wuxi, Wuxi, Jiangsu, China"
      ],
      "name": "Yunnan Lu"
    },
    {
      "affiliations": [
        "Department of Neurology, Shanghai Seventh People’s Hospital, Shanghai, Shanghai, China"
      ],
      "name": "Feng Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong, China"
      ],
      "name": "Lei Mu"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"
      ],
      "name": "Zequn Li"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China"
      ],
      "name": "Jianfeng Han"
    },
    {
      "affiliations": [
        "Department of Interventional Neuroradiology, The First People’s Hospital of Lianyungang City, Lianyungang, China"
      ],
      "name": "Yong Sun"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, China"
      ],
      "name": "Hao Qin"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China",
        "Department of Interventional Neuroradiology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Liqun Jiao"
    },
    {
      "affiliations": [
        "Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"
      ],
      "name": "QinJian Sun"
    },
    {
      "affiliations": [],
      "name": "SUCTION study Investigators"
    }
  ],
  "title": "Design of aSpiration based thrombectomy in acUte large vessel oCclusive sTroke with dIfferent etiOlogies: a real-world multiceNtre (SUCTION) study",
  "uid": "d34bac67-dde2-50f7-9534-a169a0a41732"
}