{
  "abstract": "Objective To assess the incidence of delirium and its predictors among adult patients admitted to the intensive care units of comprehensive specialised hospitals in the Amhara region of northwest Ethiopia from 18 October 2024 to 20 February 2025.Design A multicentre prospective observational study was conducted.Setting Four comprehensive specialised hospitals in the Amhara region of northwest Ethiopia, from 18 October 2024 to 20 February 2025.Participants A total of 351 patients were included in the final analysis during the study period.Outcome measures The primary outcome measure of this study was the incidence of delirium. Additionally, the study investigated the factors associated with delirium incidence among adult patients admitted to intensive care units.Results The incidence of delirium among adult patients in intensive care units was 42.17% (95% CI: 37.08 to 47.42). Pain (adjusted HR (AHR) = 4.74; 95% CI: 2.38 to 9.44), mechanical ventilation (AHR = 2.96; 95% CI: 1.56 to 5.63), age 65 years or older (AHR = 2.18; 95% CI: 1.48 to 3.21) and agitation (Richmond Agitation-Sedation Scale (RASS) ≥1) (AHR = 3.26; 95% CI: 2.09 to 5.09) were statistically significant factors associated with delirium.Conclusion and recommendation In the present study, more than one-third of patients developed delirium. Pain, mechanical ventilation, age 65 or older and agitation (RASS≥1) were significantly associated with delirium occurrence. To reduce the incidence of delirium, the current study recommends treating or preventing pain and agitation. Additionally, special attention should be given to patients receiving mechanical ventilation and those aged 65 or older during care.",
  "authors": [
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Temesgen Brilie Asmare"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Habtie Bantider Wubet"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Negesse Zurbachew Gobezie"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Getachew Mekete Deress"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Kumlachew Geta Belete"
    },
    {
      "affiliations": [
        "Department of Anesthesia, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia"
      ],
      "name": "Molla Amsalu Tadesse"
    },
    {
      "affiliations": [
        "Department of Pediatrics and Neonatal Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Abere Gebru Abuhay"
    },
    {
      "affiliations": [
        "Department of Environmental health, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Biruk Demissie"
    },
    {
      "affiliations": [
        "Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Amanu Addis Melesew"
    },
    {
      "affiliations": [
        "Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Walelign Asmie Afework"
    },
    {
      "affiliations": [
        "Department of Anesthesia, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia"
      ],
      "name": "Yewlsew Fentie Alle"
    },
    {
      "affiliations": [
        "Department of Anesthesia, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia"
      ],
      "name": "Daniel Getaneh Demite"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Diriba Teshome"
    },
    {
      "affiliations": [
        "Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Kaletsidk Dessalegn Mossie"
    },
    {
      "affiliations": [
        "Department of Emergency and Critical Care Medicine, Debre Tabor University, Debre Tabor, Ethiopia"
      ],
      "name": "Belayneh Dessie Kassa"
    },
    {
      "affiliations": [
        "Department of Neonatal Health Nursing, School of Nursing, College of Medicine and Health Sciences, and Specialized Hospital, University of Gondar, Gondar, Ethiopia"
      ],
      "name": "Gezahagn Demsu Gedefaw"
    }
  ],
  "title": "Incidence and predictors of delirium in patients admitted to intensive care unit at comprehensive specialised hospitals in Amhara region, northwest Ethiopia: a multicentre prospective observational study",
  "uid": "ee3cd206-54c9-573d-92d8-2f87e7df29d7"
}