{
  "abstract": "Objective Advanced or recurrent endometrial carcinoma (EC) represents a significant clinical challenge. This study aimed to evaluate patient (age and comorbidities) and disease (histological subtypes and stages) characteristics, treatment patterns and survival outcomes in a real-world French healthcare setting.Methods and analysis In this national, multi-centre, retrospective observational cohort study, 200 patients with advanced or recurrent EC receiving first- or second-line chemotherapy during the year 2019 were analysed. Data collected included baseline characteristics, treatment regimens, real-world progression-free survival (rwPFS) and overall survival (OS).Results 127 and 73 were included in the first and second lines, respectively. Endometrioid carcinoma was the most represented histological subtype (62.0%). Patients in the first line, of whom 31.5% had FIGO (Fédération Internationale de Gynécologie Obstétrique) IVB disease, mainly received a combination of carboplatin and paclitaxel (78.0%), while 131 patients receiving second-line therapy were mainly administered anthracycline (54.2%). Median rwPFS and OS were, respectively, 8.5 and 13.2 months for patients receiving first-line therapy and 4.0 and 9.4 months for patients receiving second-line therapy. In Cox analyses, a diagnosis of carcinosarcoma, the presence of liver metastases and stage IVB disease were associated with worse survival outcomes for patients recieving first-line chemotherapy. Non-platinum chemotherapy and liver metastases were associated with poorer survival in patients receiving second-line chemotherapy.Conclusions This study highlights the landscape of metastatic EC treatment in a real-world French setting before the availability of PD1 inhibitors, emphasising the discrepancy between clinical trial data and real-world outcomes. It underscores the necessity for further real-world studies to complement clinical trials for a comprehensive understanding of metastatic EC management.",
  "authors": [
    {
      "affiliations": [
        "Université Paris Cité, Paris, Île-de-France, France",
        "Hôpital Cochin, Paris, Île-de-France, France"
      ],
      "name": "Jerome Alexandre"
    },
    {
      "affiliations": [
        "ICANS, Strasbourg, Grand Est, France"
      ],
      "name": "Philippe Boudier"
    },
    {
      "affiliations": [
        "Sainte Catherine Institute, Avignon, Provence-Alpes-Côte d’Azur, France"
      ],
      "name": "Elise Lavit"
    },
    {
      "affiliations": [
        "ARCAGY-GINECO, Paris, France"
      ],
      "name": "Bernard Asselain"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France"
      ],
      "name": "Sheik Emambux"
    },
    {
      "affiliations": [
        "Institut de Cancérologie de l’Ouest Site René Gauducheau, Saint Herblain, Pays de la Loire, France"
      ],
      "name": "Dominique Berton"
    },
    {
      "affiliations": [
        "Department of Surgery, Institut Bergonié, Bordeaux, France",
        "ARTiSt Lab, Université de Bordeaux, INSERM U1312, F-33000, Bordeaux, France"
      ],
      "name": "Guillaume Babin"
    },
    {
      "affiliations": [
        "Centre Eugène Marquis, Rennes, Bretagne, France"
      ],
      "name": "Céline Lescure"
    },
    {
      "affiliations": [
        "Centre Léon Bérard, Lyon, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Pierre-Etienne Heudel"
    },
    {
      "affiliations": [
        "Institut Curie, Departement d’Oncologie Medicale, Paris, Île-de-France, France"
      ],
      "name": "Hélène Salaun"
    },
    {
      "affiliations": [
        "Hôpital Européen Georges Pompidou Cancérologie, Paris, France"
      ],
      "name": "Nicolas Delanoy"
    },
    {
      "affiliations": [
        "Centre Hospitalier Régional d’Orléans, Orleans, Centre-Val de Loire, France"
      ],
      "name": "Heba Dawood"
    },
    {
      "affiliations": [
        "Centre d’Oncologie et de Radiothérapie 37 (ROC37), CHAMBRAY-LES-TOURS, France"
      ],
      "name": "Pierre Combe"
    },
    {
      "affiliations": [
        "Centre ONCOGARD, Institut de Cancérologie du Gard, Nîmes, France"
      ],
      "name": "Delphine Duliège"
    },
    {
      "affiliations": [
        "Service d’Oncologie Médicale, Groupe Hospitalier Diaconesses Croix Saint-Simon Site Avron, Paris, Île-de-France, France"
      ],
      "name": "Frederic Selle"
    },
    {
      "affiliations": [
        "MSD France SAS, Puteaux, France"
      ],
      "name": "Antoinette Hakmé"
    },
    {
      "affiliations": [
        "MSD France SAS, Puteaux, France"
      ],
      "name": "Lauren Cagnan"
    },
    {
      "affiliations": [
        "MSD France SAS, Puteaux, France"
      ],
      "name": "Nicolas Offner"
    },
    {
      "affiliations": [
        "Centre Georges-François Leclerc, Dijon, Bourgogne-Franche-Comté, France"
      ],
      "name": "Julie Niogret"
    },
    {
      "affiliations": [
        "Institut Gustave-Roussy, Villejuif, Île-de-France, France"
      ],
      "name": "Patricia Pautier"
    },
    {
      "affiliations": [
        "Centre Hospitalier Intercommunal de Créteil, Creteil, France"
      ],
      "name": "Zineb Sellam"
    },
    {
      "affiliations": [
        "Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, Grand Est, France"
      ],
      "name": "Manuel Gomes David"
    },
    {
      "affiliations": [
        "Groupe Hospitalier Mutualiste de Grenoble, Grenoble, Rhône-Alpes, France"
      ],
      "name": "Adrien Monard"
    },
    {
      "affiliations": [
        "Centre CARIO-HPCA, PLERIN-SUR-MER, France"
      ],
      "name": "Anne-Claire Hardy-Bessard"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Centre Oscar Lambret, Lille, France"
      ],
      "name": "Charlotte Bellier"
    },
    {
      "affiliations": [
        "Hôpital privé du Confluent, Nantes, Pays de la Loire, France"
      ],
      "name": "Alain Lortholary"
    },
    {
      "affiliations": [
        "Centre Hospitalier Universitaire de Dijon, Dijon, Bourgogne-Franche-Comté, France"
      ],
      "name": "Marie Chaix"
    },
    {
      "affiliations": [
        "Centre Antoine Lacassagne, Nice, Provence-Alpes-Côte d’Azur, France"
      ],
      "name": "Philippe Follana"
    },
    {
      "affiliations": [
        "Centre Hospitalier Universitaire de Brest, Brest, Bretagne, France"
      ],
      "name": "Laura Deiana"
    },
    {
      "affiliations": [
        "Médipôle de Nancy, Nancy, France"
      ],
      "name": "Laurène Gavoille"
    },
    {
      "affiliations": [
        "Centre Hospitalier Victor Dupouy d’Argenteuil, Argenteuil, Île-de-France, France"
      ],
      "name": "Gregory Manuceau"
    },
    {
      "affiliations": [
        "Hôpital Louis-Mourier, Colombes, Île-de-France, France"
      ],
      "name": "Sadji Djennaoui"
    },
    {
      "affiliations": [
        "Hôpital Bretonneau, Tours, Centre, France"
      ],
      "name": "Mathilde Cancel"
    },
    {
      "affiliations": [
        "Centre Hospitalier Universitaire de Besancon, Besancon, Bourgogne-Franche-Comté, France"
      ],
      "name": "Elsa Kalbacher"
    },
    {
      "affiliations": [
        "Université Paris Cité, Paris, Île-de-France, France",
        "Hôpital Cochin, Paris, Île-de-France, France"
      ],
      "name": "Sixtine De Percin"
    }
  ],
  "title": "Clinical outcome of advanced or recurrent endometrial carcinoma treated with chemotherapy: a French observational retrospective cohort: the ENDOVIE study",
  "uid": "4566d391-9a95-5991-8d47-8d9c0580a3f4"
}