{
  "abstract": "Introduction Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited. The OxyFOB study aims to assess the prevalence and outcomes of various oxygenation and ventilatory support strategies used during FB across Europe.Methods and analysis The OxyFOB study is a large, prospective, international, observational cohort study which aims to involve over 10 000 FB procedures across European centres. Eligible participants include all adults undergoing FB for diagnostic, therapeutic or procedural indications. Data are collected via a standardised electronic case report form and encompass demographic information, procedural details and clinical outcomes. The primary endpoint is the prevalence of oxygenation and ventilatory support strategies: conventional oxygen therapy, high-flow oxygen therapy, continuous positive airway pressure, non-invasive ventilation and invasive mechanical ventilation. Secondary outcomes include periprocedural respiratory and haemodynamic events, patient comfort, dyspnoea and postprocedural complications. Statistical analyses include descriptive statistics, subgroup comparisons and multivariate logistic regression.Ethics and dissemination The study has received ethical approval from the coordinating centre (protocol n. 22/2022 on the 20 January 2022, by the ‘Comitato Etico Sezione Area Centro - Regione Calabria’) and all participating sites. Informed consent is given from all patients or their legal representatives. Findings will be disseminated through peer-reviewed publications and presentations at international meetings. Data will be managed and made available on reasonable request to support further research.Trial registration number ClinicalTrials.gov ID: NCT05681962. Registered January 2023.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy"
      ],
      "name": "Federico Longhini"
    },
    {
      "affiliations": [
        "Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"
      ],
      "name": "Claudia Crimi"
    },
    {
      "affiliations": [
        "Department of Human Pathology of the adult and evolutive age \"Gaetano Barresi”, University of Messina, Messina, Italy"
      ],
      "name": "Alberto Noto"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy"
      ],
      "name": "Corrado Pelaia"
    },
    {
      "affiliations": [
        "University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Teaching and Research Hospital, Istanbul, Turkey"
      ],
      "name": "Zuhal Karakurt"
    },
    {
      "affiliations": [
        "Medical University of Silesia, Ruda Slaska, Poland"
      ],
      "name": "Szymon Skoczyński"
    },
    {
      "affiliations": [
        "Hospital Prof. Doutor Fernando Fonseca, ULS Amadora-Sintra, Amadora, Portugal"
      ],
      "name": "José Pedro Boléo-Tomé"
    },
    {
      "affiliations": [
        "Universidade do Porto Faculdade de Medicina, Porto, Portugal"
      ],
      "name": "João Carlos Winck"
    },
    {
      "affiliations": [
        "Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain"
      ],
      "name": "Antonio M Esquinas"
    },
    {
      "affiliations": [
        "Respiratory Medicine Unit and NIHR Oxford Biomedical Research Centre, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK"
      ],
      "name": "James Melhorn"
    },
    {
      "affiliations": [
        "Central Military Emergency University Hospital, University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania"
      ],
      "name": "Dan Corneci"
    },
    {
      "affiliations": [
        "Louis Pasteur University Hospital, Kosice, Slovakia"
      ],
      "name": "Pavol Pobeha"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy"
      ],
      "name": "Vincenzo Bosco"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy"
      ],
      "name": "Eugenio Garofalo"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy"
      ],
      "name": "Andrea Bruni"
    },
    {
      "affiliations": [
        "Department of Translational Medicine, University of Novara Faculty of Medicine and Surgery, Novara, Italy"
      ],
      "name": "Gianmaria Cammarota"
    },
    {
      "affiliations": [
        "Anesthesia and ICU, Centre Hospitalier Annecy Genevois, Épagny Metz-Tessy, France"
      ],
      "name": "Violeta Todorova"
    },
    {
      "affiliations": [
        "Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, Sassari University Hospital, Sassari, Italy"
      ],
      "name": "Mariangela Valentina Puci"
    },
    {
      "affiliations": [
        "Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, Sassari University Hospital, Sassari, Italy"
      ],
      "name": "Giovanni Sotgiu"
    },
    {
      "affiliations": [
        "Respiratory Medicine Department, University of Ioannina Faculty of Medicine, Ioannina, Greece"
      ],
      "name": "Konstantinos Kostikas"
    },
    {
      "affiliations": [
        "Department of Anesthesiology and Intensive Care Medicine - Miulli University Hospital, LUM University of Casamassima, Acquaviva delle fonti, Italy"
      ],
      "name": "Salvatore Maurizio Maggiore"
    },
    {
      "affiliations": [
        "Department of Medicine and Surgery, University of Perugia, Perugia, Italy"
      ],
      "name": "Edoardo De Robertis"
    },
    {
      "affiliations": [
        "Department of Pulmonary and Critical Care, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
      ],
      "name": "Begum Ergan"
    },
    {
      "affiliations": [
        "Vita-Salute San Raffaele University, Milano, Italy"
      ],
      "name": "Giovanni Landoni"
    },
    {
      "affiliations": [
        "Department of Medicine and Surgery, University of Perugia, Perugia, Italy"
      ],
      "name": "Rachele Simonte"
    },
    {
      "affiliations": [
        "Alma Mater Studiorum University of Bologna, Bologna, Italy"
      ],
      "name": "Stefano Nava"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Padua, Padova, Italy"
      ],
      "name": "Paolo Navalesi"
    },
    {
      "affiliations": [
        "San Donato Hospital, Arezzo, Italy"
      ],
      "name": "Raffaele Scala"
    },
    {
      "affiliations": [],
      "name": "OxyFOB study group"
    }
  ],
  "title": "Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol",
  "uid": "ba75f7c0-9bc2-5b10-9539-ae17a494e171"
}