{
  "abstract": "Introduction IgA nephropathy (IgAN) is the most common primary glomerular disease in adults. In recent years, there have been many significant advances in treating IgAN, with multiple successful clinical trials. We aim to determine the comparative effectiveness of available pharmaceutical interventions for treating IgAN.Methods and analysis A systematic review and network meta-analysis (NMA) will be conducted to assess the comparative effectiveness and safety of various pharmacological interventions available for adults with IgAN. All randomised controlled trials (RCTs) or quasi-RCTs which have evaluated pharmacological interventions in IgAN will be included. Both published studies and those available only as conference abstracts will be considered. A systematic literature search will be conducted using Ovid MEDLINE(R) ALL, Embase, Cochrane Kidney and Transplant Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), WHO International Clinical Trials Registry and ClinicalTrials.gov from inception to the present. Data extraction and risk of bias assessments using Cochrane Risk of Bias 2.0 will be performed by two reviewers independently, and differences resolved through consensus. Primary outcomes assessed will be kidney function and death, and secondary outcomes will be cardiovascular disease, other adverse events and patient-reported outcomes. The NMA will be conducted using a Bayesian NMA with Markov Chain Monte Carlo simulation methods in a random-effects model framework. The certainty of the evidence will be assessed using the Confidence In Network Meta-Analysis(CINeMA) tool to manage the Grading of Recommendations, Assessment, Development and Evaluations(GRADE) assessment.After initial publication, the NMA will be maintained as a ‘living model’ in an open-source web application. A living ‘auto-search’ will be created and updated monthly to identify new evidence as it becomes available for synthesis. If new relevant studies are identified, after risk of bias assessment, data will be extracted and incorporated into the model, and findings will be updated accordingly. This will potentially provide a continuous overview of the rapidly changing therapeutic landscape of IgAN in the coming years and in future may help us to design ‘living guidelines’ for the management of IgAN.Ethics and dissemination The findings will be published in international peer-reviewed journals. No results are being presented in this protocol.PROSPERO registration number CRD420251050367.",
  "authors": [
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia",
        "Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India"
      ],
      "name": "Soumita Bagchi"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Armando Teixeira-Pinto"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia",
        "College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia"
      ],
      "name": "Nida Saleem"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Anh Kieu"
    },
    {
      "affiliations": [
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia",
        "Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy"
      ],
      "name": "Giovanni Strippoli"
    },
    {
      "affiliations": [
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia",
        "Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy"
      ],
      "name": "Patrizia Natale"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Chandana Guha"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Nicole Jane Scholes-Robertson"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Edmund Chung"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "David Tunnicliffe"
    },
    {
      "affiliations": [
        "Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia",
        "Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia",
        "Department of Renal and Transplantation Medicine, Westmead Hospital, Westmead, New South Wales, Australia"
      ],
      "name": "Germaine Wong"
    }
  ],
  "title": "Pharmacological interventions in IgA nephropathy: protocol for a living systematic review and network meta-analysis",
  "uid": "72857295-e71e-57ff-8b75-8a3b5f6c903d"
}