{
  "abstract": "Objective We hypothesised that all-cause mortality in elderly patients with obstructive sleep apnoea syndrome (OSAS) was associated with renal insufficiency.Design A cohort study.Setting A prospective study of patients with OSAS enrolled in sleep centres/departments in multicentre hospitals in China from 2015 to 2017.Participants A total of 1290 patients with OSAS from six tertiary comprehensive hospitals in China were included in this study; of these, 1076 patients were included in the analysis based on inclusion and exclusion criteria.Main outcome measures All-cause death events were the main adverse outcomes.Result During a median follow-up of 42 months, 50 patients (4.6%) died, including 24 (2.2%) cardiovascular deaths. The incidence of all-cause death and cardiovascular death was higher in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m 2 than in the other groups (p<0.001). Multivariate Cox regression models showed that patients with low levels of eGFR had a higher risk of all-cause death compared with patients with high levels of eGFR (HR=8.954, 95% CI, 2.108 to 38.033; p=0.003) and cardiovascular death risk (HR=4.163, 95% CI, 1.524 to 11.375; p=0.005).Conclusion The incidence of all-cause death and cardiovascular death events increased with decreasing renal function in elderly patients with OSAS and was higher in patients with end-stage renal insufficiency. The risk of all-cause and cardiovascular deaths was highest at eGFR below 30 mL/min/1.73 m 2.",
  "authors": [
    {
      "affiliations": [
        "Peking University International Hospital, Beijing, China"
      ],
      "name": "Yinghui Gao"
    },
    {
      "affiliations": [
        "Chinese PLA General Hospital, Beijing, China",
        "The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China"
      ],
      "name": "Fengfeng Fang"
    },
    {
      "affiliations": [
        "People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, China"
      ],
      "name": "Zuo Zhang"
    },
    {
      "affiliations": [
        "Department of Vasculocardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China"
      ],
      "name": "Libo Zhao"
    },
    {
      "affiliations": [
        "Department of Vasculocardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China"
      ],
      "name": "Zhe Zhao"
    },
    {
      "affiliations": [
        "Medical College, Yan’an University, Yan’an, Shaanxi, China"
      ],
      "name": "Zijun He"
    },
    {
      "affiliations": [
        "Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China, Communist Party of China General Office of the Central Committee Security Bureau, Beijing, China"
      ],
      "name": "Kailiang Li"
    },
    {
      "affiliations": [
        "Medical College, Yan’an University, Yan’an, Shaanxi, China"
      ],
      "name": "Hongyan Bian"
    },
    {
      "affiliations": [
        "Department of Pulmonary and Critical Care Medicine of the Second Medical Center, Chinese PLA General Hospital, Beijing, China"
      ],
      "name": "Lin Liu"
    }
  ],
  "title": "Effect of obstructive sleep apnoea syndrome combined with renal insufficiency on all-cause mortality in elderly patients in China: a prospective cohort study",
  "uid": "0efa5d14-80f4-5131-a7cd-f0681fc4427e"
}