{
  "abstract": "Moyamoya disease (MMD) is a rare cerebrovascular disease characterised by gradual progressive stenosis and occlusion of the terminal internal carotid arteries, anterior cerebral arteries and proximal middle cerebral arteries bilaterally. This pathology leads to the formation of a compensatory and fragile collateral vascular network at the brain’s base. With disease progression, MMD may result in ischaemic or haemorrhagic stroke. However, the lack of reliable and effective methods to assess disease progression leaves many patients at high risk of stroke without timely clinical intervention. Therefore, determining the disease course and assessing stroke risk are critical. Cerebrovascular reserve (CVR) reflects the ability of brain tissue to increase blood flow under stress. CVR evaluation assists clinicians in understanding MMD severity, guiding therapeutic decisions and determining prognosis. This narrative review analyses recent literature, highlights the advantages and disadvantages of various CVR assessment techniques, and discusses the interplay between CVR and MMD. In addition, it examines the role of CVR in evaluating disease progression and associated treatments.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Siyu Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Tianrui Yu"
    },
    {
      "affiliations": [
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Yuanyuan Xiang"
    },
    {
      "affiliations": [
        "Department of Imaging, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China"
      ],
      "name": "Liang Chen"
    },
    {
      "affiliations": [
        "Department of Imaging, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China"
      ],
      "name": "Hao Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China",
        "University of Shanghai for Science and Technology, Shanghai, China"
      ],
      "name": "Xuezhi Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Xianming Cao"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Yanghang Chen"
    },
    {
      "affiliations": [
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Manqing Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China"
      ],
      "name": "Xiaoping Yin"
    },
    {
      "affiliations": [
        "Department of Neurology, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, China",
        "Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China",
        "Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences, Jiujiang University, Jiujiang, Jiangxi, China"
      ],
      "name": "Zhiying Chen"
    }
  ],
  "title": "Advances in cerebrovascular reserve function assessment for moyamoya disease",
  "uid": "a94f0742-fc18-5b1c-b13d-134adbc28555"
}