{
  "abstract": "Introduction Following a cerebrovascular event, the associated risks for further major adverse cerebro- and cardiovascular events and death (MACE) and important aspects of cognitive, mental and patient-reported outcomes are currently not understood, particularly long-term. Here, we present the study design of the ongoing Berlin Long-term Observation of Vascular Events (BeLOVE) stroke stratum and report data of the first study phase.Methods and analysis BeLOVE is a prospective, longitudinal, observational, hospital-based cohort study. Its stroke stratum enrols adult patients with acute ischaemic stroke, transient ischaemic attack (TIA) or non-traumatic intracerebral haemorrhage. Patients undergo deep phenotyping including cerebral and cardiac MRI, ECG, echocardiography and bio-sampling including multi-omics analyses. Regular, standardised follow-ups take place annually over a period of up to 10 years and record the frequency of MACE as the primary outcome.Secondary outcomes include the frequency, progression and interactions of functional impairments, namely post-stroke cognition, pain, depression, seizures and their relationship to quality of life.The first study phase included 758 patients (median 69 years, 37% female). At 2-year follow-up, the cumulative incidence (95% CI) of the composite primary endpoint MACE was 0.107 (0.085 to 0.132) and that of first ischaemic stroke, first myocardial infarction and death were 0.066 (0.049 to 0.086), 0.015 (0.008 to 0.026) and 0.040 (0.027 to 0.056), respectively.Ethics and dissemination Each participant will provide informed written consent during the acute in-hospital phase. Data will be available for research purposes via a written request to the data use and access committee.Trial registration number German Clinical Trials Register: http://www.drks.de/DRKS00023323 on 4 November 2020.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Center for Stroke Research Berlin (CSB), Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany",
        "BIH, Berlin, Germany",
        "German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), DZNE, Berlin, Germany"
      ],
      "name": "Christian H Nolte"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Joachim E Weber"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Michael Ahmadi"
    },
    {
      "affiliations": [
        "DHZC, Berlin, BE, Germany"
      ],
      "name": "Leif-Hendrik Boldt"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany"
      ],
      "name": "Tim B Braemswig"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany",
        "DKTK, Heidelberg, Germany"
      ],
      "name": "Frederik Damm"
    },
    {
      "affiliations": [
        "Charité - Universitätsmedizin Berlin, Berlin, Germany"
      ],
      "name": "Jakob I Doerrfuss"
    },
    {
      "affiliations": [
        "Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany"
      ],
      "name": "Kai-Uwe Eckardt"
    },
    {
      "affiliations": [
        "DHZC, Berlin, BE, Germany"
      ],
      "name": "Frank Edelmann"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany"
      ],
      "name": "Ivana Galinovic"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany",
        "Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Buch, Germany",
        "DZHK, Berlin, Germany"
      ],
      "name": "Holger Gerhardt"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Institute of Biometry and Clinical Epidemiology, Berlin, Germany",
        "Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany"
      ],
      "name": "Ulrike Grittner"
    },
    {
      "affiliations": [
        "Max Delbruck Centre for Molecular Medicine in the Helmholtz Association, Buch, BE, Germany"
      ],
      "name": "Norbert Hübner"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Institute of Biometry and Clinical Epidemiology, Berlin, Germany"
      ],
      "name": "Jil Heege"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany"
      ],
      "name": "Anna Kufner"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Department of Neurology, Carl von Ossietzky Universitat Oldenburg, Oldenburg, NDS, Germany",
        "DZNE, Berlin, Germany"
      ],
      "name": "Thomas Liman"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany"
      ],
      "name": "Andreas Meisel"
    },
    {
      "affiliations": [
        "Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Buch, Germany",
        "DZHK, Berlin, Germany"
      ],
      "name": "Dominik N Müller"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany",
        "Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "DZPG, Mannheim, BW, Germany"
      ],
      "name": "Christian Otte"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Rafaela M Pinto"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Institute of Biometry and Clinical Epidemiology, Berlin, Germany"
      ],
      "name": "Sophie Piper"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Institute of Biometry and Clinical Epidemiology, Berlin, Germany"
      ],
      "name": "Simrit Rattan"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany",
        "DZNE, Berlin, Germany"
      ],
      "name": "Regina I von Rennenberg"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Ira Rohrpasser-Napierkowski"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany",
        "DZHK, Berlin, Germany"
      ],
      "name": "Jan F Scheitz"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Katharina Schoenrath"
    },
    {
      "affiliations": [
        "Max Delbruck Centre for Molecular Medicine in the Helmholtz Association, Buch, BE, Germany",
        "Department of Cardiology and Nephrology, HELIOS Klinikum Berlin-Buch, Berlin, Germany"
      ],
      "name": "Jeanette Schulz-Menger"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Oliver Schweizerhof"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany"
      ],
      "name": "Pia S Sperber"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "BIH, Berlin, Germany"
      ],
      "name": "Lena Steindorf-Sabath"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "BIH, Berlin, Germany"
      ],
      "name": "Alina Stegemann"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany"
      ],
      "name": "Helena Stengl"
    },
    {
      "affiliations": [
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany"
      ],
      "name": "Kersten Villringer"
    },
    {
      "affiliations": [
        "BIH, Berlin, Germany",
        "DHZC, Berlin, BE, Germany"
      ],
      "name": "Ulf Landmesser"
    },
    {
      "affiliations": [
        "Department of Endocrinology and Metabolism",
        "European Reference Network on Rare Endocrine Diseases (ENDO-ERN), Charité - Universitätsmedizin Berlin, Berlin, Germany"
      ],
      "name": "Knut Mai"
    },
    {
      "affiliations": [
        "Max Delbruck Centre for Molecular Medicine in the Helmholtz Association, Buch, BE, Germany"
      ],
      "name": "Tobias Pischon"
    },
    {
      "affiliations": [
        "Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
        "Charité University Hospital Berlin Center for Stroke Research Berlin, Berlin, Germany",
        "DZHK, Berlin, Germany",
        "DZNE, Bonn, NRW, Germany"
      ],
      "name": "Matthias Endres"
    }
  ],
  "title": "Stroke and its consequences: protocol and pilot data of the observational Berlin Long-term Observation of Vascular Events (BeLOVE) stroke stratum",
  "uid": "17e760e4-e6a9-5eab-8038-8e706026c0db"
}