{
  "abstract": "Background and purpose Although systolic blood pressure variation (ΔSBP) has been regarded as a predictor of poor outcome after endovascular therapy (EVT), its effect at the different time intervals on the prognosis of acute anterior large vessel occlusion remains unclear. The study aims to assess the impact of ΔSBP at different time intervals on futile recanalisation (FRT) of acute anterior circulation large-vessel occlusion stroke after EVT.Methods A total of 554 consecutive patients who achieved successful recanalisation after EVT were enrolled from the Effect of Endovascular Treatment Alone versus Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients with Acute Ischemic Stroke (DEVT) and Effect of Intravenous Tirofiban versus Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke (RESCUE BT) trials. ΔSBP was defined as SBP max minus SBP min at different time intervals, including 0–6 hours, 6–12 hours and 12–24 hours after EVT. The primary outcome was FRT at 90 days, defined as a modified Rankin Scale score of 3 to 6. The secondary outcome was symptomatic intracranial haemorrhage within 48 hours.Results Among these patients, 278 patients underwent FRT and 276 achieved useful recanalisation at 90 days. ΔSBP 0–6 hours was found to be positively associated with an increased likelihood of FRT (adjusted OR (aOR) per 5 mm Hg SBP change, 1.014, 95% CI 1.002 to 1.026). Large variation of SBP (ΔSBP >40 mm Hg) in the first 6 hours had a higher probability of FRT (aOR, 1.817, 95% CI 1.059 to 3.117) compared with a ΔSBP of 0–20 mmHg.Conclusion SBP variation within the first 6 hours after EVT was associated with FRT. Large fluctuations (ΔSBP >40 mm Hg) of SBP in 0–6 hours following EVT were found to increase the probability of FRT.",
  "authors": [
    {
      "affiliations": [
        "Yunyang County People’s Hospital, Chongqing, China"
      ],
      "name": "Tieying Cai"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Jiandi Huang"
    },
    {
      "affiliations": [
        "People’s Hospital of Zunyi City Bo Zhou District, Zunyi, China"
      ],
      "name": "Shuang Yang"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Dongjing Xie"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Yuting Guo"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Jie Yang"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Dahong Yang"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Jinrong Hu"
    },
    {
      "affiliations": [
        "Department of Neurology, Army Medical University Xinqiao Hospital, Chongqing, China"
      ],
      "name": "Fengli Li"
    }
  ],
  "title": "Blood pressure variation and futile recanalisation in patients with large-vessel occlusion after endovascular therapy",
  "uid": "4d61da38-7f51-53a1-bce8-ee520a6b976f"
}