{
  "abstract": "Background Migraine is a common comorbidity in patients with cervical dystonia (CD); however, the diagnosis of chronic migraine (CM) in patients with cervical dystonia (CD) is unknown.Methods This observational retrospective cohort study used longitudinal patient-level data from the Optum Market Clarity Database in the US. CD cohort includes patients ≥18y with ≥2CD diagnoses ≥30d apart during the study (January 2017 - September, 2021) and ≥180d of continuous health plan enrolment prior to cohort entry (first CD diagnosis coding). Cohort 1:CD+migraine/headache patients; cohort 2: CD+CM patients; cohorts 3 and 4: CD+CM BoNT treated and BoNT-untreated patients, respectively. Assessments include diagnosis, demographics and clinical characteristics of migraine/headache in the CD cohort.Results Of 81,884 CD patients, 36.1% had migraine/headache (cohort 1, n=29,533), 12.6% had concurrent CM (cohort 2, n=10,284). There were more CD+CM patients in cohort 4(BoNT-untreated) compared to cohort 3 (BoNT-treated) (57.4% vs 42.6%). Common comorbidities were comparable across cohorts 1–4 (neck pain, range: 63.6% - 78.8%; psychiatric conditions, range: 37.5% - 43.3%). The proportion of patients with psychiatric conditions in the CD+CM cohort was greater compared to the overall CD cohort (42.9% vs 28.1%). CD+CM patients treated with BoNT for both CD and CM diagnoses were higher (24.6%) than those treated for CD or CM individually (19.6% and 16.6%)Conclusion This study provides evidence that CM is a common comorbidity in CD patients and therefore underscores the importance of diagnosis and selection of appropriate treatment options for managing these disease states.",
  "authors": [
    {
      "affiliations": [
        "Neurology One, University of Central Florida, Orlando, Florida, USA"
      ],
      "name": "Ramon Rodriguez"
    },
    {
      "affiliations": [
        "Weill Cornell Medicine, New York, NY, USA"
      ],
      "name": "Susan W Broner"
    },
    {
      "affiliations": [
        "NeuroPain Care Center, NYU Langone, New Hyde Park, NY, USA"
      ],
      "name": "Grace Forde"
    },
    {
      "affiliations": [
        "Norton Neuroscience Institute, Louisville, Kentucky, USA"
      ],
      "name": "Christopher Rhyne"
    },
    {
      "affiliations": [
        "Abbvie, Irvine, California, USA"
      ],
      "name": "Marjan Sadeghi"
    },
    {
      "affiliations": [
        "Abbvie, North Chicago, IL, USA"
      ],
      "name": "Emma Xiaomeng"
    },
    {
      "affiliations": [
        "Abbvie, Irvine, California, USA"
      ],
      "name": "Ahunna Ukah"
    },
    {
      "affiliations": [
        "Abbvie, Irvine, California, USA"
      ],
      "name": "Kim Becker Ifantides"
    },
    {
      "affiliations": [
        "Weill Cornell Medicine, New York, NY, USA"
      ],
      "name": "Harini Sarva"
    },
    {
      "affiliations": [
        "Abbvie, Mascot, NSW, Australia"
      ],
      "name": "Juanita Kidd"
    }
  ],
  "title": "3466 Real-world diagnosis of chronic migraine in patients with cervical dystonia analyzed by botulinum neurotoxin treatment exposure: an epidemiologic perspective",
  "uid": "9a8b2217-07e7-565c-b5a4-02775e24e8ac"
}