{
  "abstract": "Background Patients with connective tissue disorders such as Marfan syndrome confer an increased risk of spontaneous intracranial hypotension as they are predisposed to structural weaknesses causing dura ectasia. Rebound intracranial hypertension can develop as an acute complication of epidural blood patches used to treat CSF leaks but has not been previously described in patients with Marfan.Case Study A 17-year-old male patient with Marfan Syndrome who presented with postural headaches was initially diagnosed with intracranial hypotension and successfully treated with an epidural blood patch targeting the spinal CSF leak identified on myelogram with complete clinical and radiological resolution. Approximately 11 months after this, he re-presented with a reversal of his postural headaches, new papilledema, and an opening pressure of 35cmH2O with features of raised intracranial pressure on a brain MRI. Rebound intracranial hypertension with this latency is infrequently reported particularly in a patient with Marfan syndrome.Conclusion This case highlights the importance in recognising this potential delayed complication of CSF leak treatment, and distinguishing between rebound intracranial hypertension and recurrence of intracranial hypotension as there are differing diagnostic and management implications.",
  "authors": [
    {
      "affiliations": [
        "Prince of Wales Hospital, Randwick, Sydney, NSW, Australia",
        "Faculty of Medicine, Randwick Clinical Campus, UNSW, Sydney, NSW, Australia"
      ],
      "name": "William Chapman"
    },
    {
      "affiliations": [
        "Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"
      ],
      "name": "Kevin Tay"
    },
    {
      "affiliations": [
        "Prince of Wales Hospital, Randwick, Sydney, NSW, Australia",
        "Faculty of Medicine, Randwick Clinical Campus, UNSW, Sydney, NSW, Australia"
      ],
      "name": "Roshan Dhanapalaratnam"
    },
    {
      "affiliations": [
        "Southern Ophthalmology, Sydney, NSW, Australia"
      ],
      "name": "Harry Leung"
    },
    {
      "affiliations": [
        "Prince of Wales Hospital, Randwick, Sydney, NSW, Australia",
        "Faculty of Medicine, Randwick Clinical Campus, UNSW, Sydney, NSW, Australia"
      ],
      "name": "Alessandro Zagami"
    },
    {
      "affiliations": [
        "Prince of Wales Hospital, Randwick, Sydney, NSW, Australia",
        "Faculty of Medicine, Randwick Clinical Campus, UNSW, Sydney, NSW, Australia",
        "Translational Research Collective, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia"
      ],
      "name": "William Huynh"
    }
  ],
  "title": "3481 Rebound intracranial hypertension following treatment for spontaneous CSF leak in a patient with marfan syndrome",
  "uid": "6ce47ed5-ca37-5020-bed0-0b82eb37d043"
}