{
  "abstract": "Background Traumatic encephalopathy syndrome (TES) is a clinical research diagnosis associated with chronic traumatic encephalopathy (CTE)- an autopsy diagnosed tauopathy associated with repetitive head trauma (RHT). The effect of RHT on OCT measures such as Retinal Nerve Fibre Layer thickness remains poorly understood, yet progressive thinning has been found in neurodegenerative disease. We sought to investigate the presence of OCT abnormalities in patients with TES.Methods 48 patients with a history of RHT from sport and military service underwent neurological and ophthalmological assessment; 27 were diagnosed clinicoradiologically with TES. Other neurological causes of TES symptoms were reasonably excluded using clinical evaluation, neuroimaging, neuropsychological measures and follow up progression.Results Mean OCT measures were compared between the TES (n=27) and no TES (n=21) groups using linear regression, accounting for greater concussion history in the TES group. The TES and no TES groups had comparable average age, cumulative and years since RHT exposure, alcohol consumption. No relationship was found between OCT measures and TES diagnosis. Pearson product analysis revealed positive correlations between OCT measures and RHT exposure, loss of consciousness concussions and Addenbrooke’s Cognitive Examination III score. Negative correlations were found between OCT measures and years since RHT exposure.Conclusion This baseline analysis found no relationship between OCT measures and TES diagnosis. The negative correlation between OCT measures and years since RHT exposure reinforces the need for longitudinal analysis of OCT measures in patients with a history of RHT.",
  "authors": [
    {
      "affiliations": [
        "Orange Health Service, Western NSW Local Health District, Orange, NSW, Australia"
      ],
      "name": "Morgan See"
    },
    {
      "affiliations": [
        "University of Notre Dame Australia School of Medicine, Fremantle, WA, Australia"
      ],
      "name": "Charlotte Gillies"
    },
    {
      "affiliations": [
        "Queensland Brain Institute, Brisbane, QLD, Australia"
      ],
      "name": "Maggie Bendersky"
    },
    {
      "affiliations": [
        "Save Sight Institute, Sydney, NSW, Australia"
      ],
      "name": "Chris Hodge"
    },
    {
      "affiliations": [
        "Macquarie Medical School, Sydney, NSW, Australia"
      ],
      "name": "Angela Schulz"
    },
    {
      "affiliations": [
        "Queensland Brain Institute, Brisbane, QLD, Australia"
      ],
      "name": "Fatima Nasrallah"
    },
    {
      "affiliations": [
        "Queensland Brain Institute, Brisbane, QLD, Australia",
        "Harbour Neurology Group, Sydney, NSW, Australia"
      ],
      "name": "Rowena Mobbs"
    },
    {
      "affiliations": [
        "Save Sight Institute, Sydney, NSW, Australia"
      ],
      "name": "Clare Fraser"
    }
  ],
  "title": "3529 Optical coherence tomography (OCT) in patients exposed to repetitive head trauma:the need for longitudinal analysis to monitor progressive OCT changes",
  "uid": "46c1df21-b3a1-5b0f-a9b0-07d0a3b8d002"
}