{
  "abstract": "Introduction One in six stroke survivors continue to experience arm and language disability at 3 months post-stroke. This study aims to identify which model(s) of integrated UPper limb and Language Impairment and Functional Training (UPLIFT) show promise for people 3 months to 24 months post-stroke. We hypothesise that at least one promising UPLIFT model of rehabilitation will be identified.Methods and analysis This is an adaptive Phase IIa master protocol umbrella design that includes four simultaneous Bayesian Optimal Phase II studies to evaluate individual UPLIFT interventions against prespecified objective performance criteria. The intervention is upper limb and language training at 2 or 4 hours/day, 5 days/week for 4 weeks, delivered either in person (severe stratum) or via telerehabilitation (mild–moderate stratum). Up to 160 adult participants will be recruited across six metropolitan/regional university or healthcare hubs spanning five Australian states. Baseline and post-intervention assessments are blinded. A promising response is defined as a composite binary outcome combining indicators of promise of efficacy, safety and feasibility. For each UPLIFT intervention, the proportion of participants with a promising response will be monitored at three equally spaced, predefined interim stopping points and one final analysis point (n=40 participants/study). An intervention will be stopped if too few promising responses are observed.Ethics and dissemination Ethical approval was obtained from The Royal Melbourne Human Research Ethics Committee. All participating sites obtained local governance approval. All recruited participants will provide informed consent. Trial results will be disseminated through peer-reviewed publications and presented at major stroke and rehabilitation conferences.Trial registration number ACTRN12622000373774.",
  "authors": [
    {
      "affiliations": [
        "Departments of Physiotherapy and Medicine, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Kathryn S Hayward"
    },
    {
      "affiliations": [
        "Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia",
        "Melbourne Brain Centre and Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Geoffrey Donnan"
    },
    {
      "affiliations": [
        "Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia",
        "Sir Charles Gairdner Osborne Park Health Care Group, Nedlands, Western Australia, Australia",
        "Edith Cowan University, Joondalup, Western Australia, Australia"
      ],
      "name": "Erin Godecke"
    },
    {
      "affiliations": [
        "Melbourne Medical School and Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia",
        "Monash University School of Translational Medicine, Melbourne, Victoria, Australia"
      ],
      "name": "Anna Balabanski"
    },
    {
      "affiliations": [
        "Cairns Institute, James Cook University, Smithfield, Queensland, Australia"
      ],
      "name": "Ruth Barker"
    },
    {
      "affiliations": [
        "Stroke Theme, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia"
      ],
      "name": "Julie Bernhardt"
    },
    {
      "affiliations": [
        "School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Sandra Brauer"
    },
    {
      "affiliations": [
        "Monash University School of Translational Medicine, Melbourne, Victoria, Australia",
        "Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia",
        "The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia"
      ],
      "name": "Amy Brodtmann"
    },
    {
      "affiliations": [
        "Department of Speech Pathology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"
      ],
      "name": "Emily Brogan"
    },
    {
      "affiliations": [
        "School of Health and Rehabilitation Sciences and Queensland Aphasia Research Centre, The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Sonia Brownsett"
    },
    {
      "affiliations": [
        "Rehabilitation Unit, Townsville University Hospital, Townsville, Queensland, Australia"
      ],
      "name": "Paul Chapman"
    },
    {
      "affiliations": [
        "School of Health and Rehabilitation Sciences and Queensland Aphasia Research Centre, The University of Queensland, Brisbane, Queensland, Australia",
        "STARS Education and Research Alliance, Metro North Hospital and Health Service, Herston, Queensland, Australia"
      ],
      "name": "David Copland"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Elise Cowley"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia",
        "Department of Occupational Therapy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Emily Dalton"
    },
    {
      "affiliations": [
        "Stroke Theme, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia"
      ],
      "name": "Fiona Ellery"
    },
    {
      "affiliations": [
        "Lived experience research partner, Melbourne, Victoria, Australia"
      ],
      "name": "Paul Fink"
    },
    {
      "affiliations": [
        "Department of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia",
        "The University of Newcastle Australia, Newcastle, New South Wales, Australia",
        "Hunter Medical Research Institute, Newcastle, New South Wales, Australia"
      ],
      "name": "Carlos Garcia Esperon"
    },
    {
      "affiliations": [
        "School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia",
        "Aphasia CRE and Department of Speech Pathology, La Trobe University, Melbourne, Victoria, Australia"
      ],
      "name": "Annie J Hill"
    },
    {
      "affiliations": [
        "School of Medicine and Public Health, and School of Health Sciences, The University of Newcastle, Newcastle, New South Wales, Australia",
        "Heart and Stroke Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia"
      ],
      "name": "Heidi Janssen"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Siobhan Kavanagh"
    },
    {
      "affiliations": [
        "Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia",
        "Department of Medicine, The University of Adelaide, Adelaide, South Australia, Australia"
      ],
      "name": "Timothy Kleinig"
    },
    {
      "affiliations": [
        "Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Liudmyla Olenko"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Joanne JE Quek"
    },
    {
      "affiliations": [
        "RECOVER Injury Research Centre, The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Trevor Russell"
    },
    {
      "affiliations": [
        "College of Healthcare Sciences, James Cook University, Townsville, Queensland, Australia",
        "La Trobe University, Melbourne, Victoria, Australia"
      ],
      "name": "Moira Smith"
    },
    {
      "affiliations": [
        "Lived experience research partner, Melbourne, Victoria, Australia"
      ],
      "name": "Lillian Taylor"
    },
    {
      "affiliations": [
        "Stroke Theme, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia",
        "Melbourne Medical School-Austin Campus, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Vincent Thijs"
    },
    {
      "affiliations": [
        "Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia",
        "Medical School, The University of Western Australia, Perth, Western Australia, Australia"
      ],
      "name": "Claire Tucak"
    },
    {
      "affiliations": [
        "Lived experience research partner, Townsville, Victoria, Australia"
      ],
      "name": "John Turner"
    },
    {
      "affiliations": [
        "Alliance Rehabilitation, Townsville, Queensland, Australia"
      ],
      "name": "Declan Wode"
    },
    {
      "affiliations": [
        "Department of Neurology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia"
      ],
      "name": "Andrew Wong"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Bronwyn Williams"
    },
    {
      "affiliations": [
        "Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia",
        "Melbourne Brain Centre and Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Bruce C V Campbell"
    },
    {
      "affiliations": [
        "Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Leonid Churilov"
    }
  ],
  "title": "Integrated UPper limb and Language Impairment and Functional Training (UPLIFT) after stroke: study protocol for an umbrella Bayesian Optimal Phase IIa clinical trial",
  "uid": "95b7ac9d-4b69-5000-b039-51da5253649e"
}