{
  "abstract": "Expected trends in population ageing and the burden of age related chronic diseases underscore the need for high quality epidemiological studies of older adults (eg, people aged 60 years and older). However, research on older adults poses unique challenges and methodological issues. Inconsistency in how the existing literature approaches these issues might contribute to observed heterogeneity in research findings and clinical uncertainty in optimal treatment and prevention guidelines. We discuss four methodological issues in ageing research (selection bias, multimorbidity, measurement error, and long latency periods) and summarise key approaches to evaluate and reduce bias. While excellent summaries of methodological challenges in epidemiological research more generally are available, 1 2 we focus on issues particularly salient for studies of older adults.",
  "authors": [
    {
      "affiliations": [
        "Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA",
        "Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"
      ],
      "name": "Emma Nichols"
    },
    {
      "affiliations": [
        "Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"
      ],
      "name": "Eleanor Hayes-Larson"
    }
  ],
  "title": "Common methodological issues in observational epidemiological studies of older adults",
  "uid": "a636af6e-170a-5c10-83a4-50d065b8a42b"
}