{
  "abstract": "Introduction The second iteration of the National Early Warning Score has been adopted widely within the UK and internationally. It uses routinely collected physiological measurements to standardise the assessment and response to acute illness. Its use is associated with reduced mortality but has limited positive and negative predictive accuracy. There is a growing body of research demonstrating the effectiveness of artificial intelligence (AI) in predicting clinical deterioration, but there is limited evidence to show which aspect of AI is best suited to this task. This systematic review aims to establish which AI or machine learning algorithm is best suited to analysing physiological data sets to predict patient deterioration in a hospital setting.Methods and analysis A systematic review will be conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) and the PICOS (Population, Intervention, Comparator, Outcome and Study) frameworks. Eight databases (PubMed, Embase, CINAHL, Cochrane Library, Web of Science, Scopus, IEEE Xplore and ACM Digital Library) will be used to search for studies published from 2007 to the present that meet the inclusion criteria. Two reviewers will screen the studies identified and extract data independently, with any discrepancies resolved by discussion. The review is expected to be completed by January 2026, and the results will be presented in publication by June 2026.Ethics and dissemination Ethical approval is not required as data will be obtained from published sources. Findings from this study will be disseminated via publication in a peer-reviewed journal.",
  "authors": [
    {
      "affiliations": [
        "Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK",
        "NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Lynsey Threlfall"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Cen Cong"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Victoria Riccalton"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK",
        "Department of Primary Care and Public Health, Imperial College London, London, UK"
      ],
      "name": "Edward Meinert"
    },
    {
      "affiliations": [
        "Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK",
        "NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK"
      ],
      "name": "Chris Plummer"
    }
  ],
  "title": "Predicting patient deterioration with physiological data using AI: systematic review protocol",
  "uid": "1b537d77-dcaf-5d46-8a94-bdeb71ae4a14"
}