{
  "abstract": "Study objective Promoting healthy lifespan equity is a pivotal challenge in the global wave of population ageing, aiming to enable the majority of people in today’s long-lived societies to reach a similar age in good health. This study aims to develop a systematic analytical framework to identify age-specific priority diseases and injuries for intervention, thereby comprehensively improving healthy lifespan equity measured by health-adjusted life expectancy (HALE, the average number of years a person can expect to live in full health).Methods First, we quantify the contribution of reducing the disease burden at each age to changes in overall HALE and healthy lifespan equity. Then, we decompose these contributions into portions attributable to mortality versus disability, ensuring no residual. Finally, we combine these weights with measures of the stability and relative importance of various causes to produce a list of priority causes for intervention across the entire life course.Results Globally, the age-specific leading causes where mortality prevention shall be a priority to achieve healthy lifespan equity are enlisted as follows: neonatal disorders (0 years), malaria (1–4 years), drowning (5–9 years), road injuries (10–24 years), HIV/AIDS (25–44 years) and ischaemic heart disease (45–84 years and over 85 years). The age-specific leading causes of disability in need of prioritisation regarding health lifespan equity are as follows: dietary iron deficiency (0–9 years), headache disorders (10–34 years), low back pain (35–69 years), age-related and other hearing loss (70–84 years) and Alzheimer’s disease and other dementias (over 85 years). Notably, the specific ranking and relative importance of these causes varied substantially by region and sex, underscoring the need for context-specific strategies.Discussion Our comprehensive framework can inform policy-makers of whether resources need to be reallocated to meet the healthy lifespan equity challenges in an ageing era.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Sun Yat-sen Global Health Institute, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Center for Health Information Research, Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Jun-Yan Xi"
    },
    {
      "affiliations": [
        "Chengdu Integrated TCM&Western Medicine Hospital (Chengdu First People's Hospital), Chengdu, Sichuan, China"
      ],
      "name": "Xue-Qi Li"
    },
    {
      "affiliations": [
        "Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Wei Hu"
    },
    {
      "affiliations": [
        "Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China"
      ],
      "name": "Jian-Jun Bai"
    },
    {
      "affiliations": [
        "Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China"
      ],
      "name": "Yi-Ning Xiang"
    },
    {
      "affiliations": [
        "Department of Maternal, Child and Adolescent Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"
      ],
      "name": "Jie Hu"
    },
    {
      "affiliations": [
        "Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China"
      ],
      "name": "Yu Liao"
    },
    {
      "affiliations": [
        "Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Sun Yat-sen Global Health Institute, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Center for Health Information Research, Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Jing Gu"
    },
    {
      "affiliations": [
        "Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Sun Yat-sen Global Health Institute, Sun Yat-sen University, Guangzhou, Guangdong, China",
        "Center for Health Information Research, Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Xiao Lin"
    },
    {
      "affiliations": [
        "Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China",
        "Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China",
        "Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China"
      ],
      "name": "Yuan-Tao Hao"
    }
  ],
  "title": "Identifying priority diseases and injuries to promote equality as measured by health-adjusted life expectancy: a population-based study",
  "uid": "868ae91a-d484-5791-9d31-26ba9a1f97a1"
}