{
  "abstract": "Objective To evaluate the association between glucagon-like peptide-1 (GLP-1) based therapy and small-bowel transit time during capsule endoscopy.Methods We conducted a prospective, multicentre, observational study of consecutive adults undergoing small-bowel capsule endoscopy for standard clinical indications. Patients receiving GLP-1-based therapy, defined as treatment with a GLP-1 receptor agonist or dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonist, were compared with non-exposed controls. The primary outcome was small-bowel transit time. Secondary outcomes included gastric transit time, capsule completion, bowel preparation quality, repeat-examination recommendation and endoscopic findings.Results Among 129 participants, 34 were receiving GLP-1-based therapy and 95 were non-exposed controls. Exposed patients had longer unadjusted small-bowel transit time than controls (median 311.0 (IQR 252.8–433.0) vs 236.0 (188.0–282.5) min; p<0.001). Gastric transit time was not significantly different between groups (33.5 (15.2–51.8) vs 22.5 (11.0–42.5) min; p=0.263). Capsule completion was numerically lower among exposed patients, but the difference was not statistically significant (91.2% vs 98.9%; p=0.056). Repeat capsule recommendation (11.8% vs 3.2%; p=0.078) and clinically significant endoscopic findings (23.5% vs 34.7%; p=0.322) were also not significantly different. In multivariable linear regression restricted to examinations with calculable small-bowel transit time and complete covariate data, GLP-1-based therapy was independently associated with longer small-bowel transit time after adjustment for age, body mass index, diabetes mellitus and indication for capsule endoscopy (adjusted β+83 min, 95% CI 3.1 to 162.8; p=0.042).Conclusion GLP-1-based therapy was associated with longer small-bowel transit time during capsule endoscopy. These findings do not support routine discontinuation of GLP-1-based therapy before capsule endoscopy, but they support individualised assessment and larger studies powered to evaluate capsule completion and repeat examination.",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Hadera, Israel",
        "Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel"
      ],
      "name": "Fadi Abu Baker"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Assuta Medical Center, Haifa, Israel"
      ],
      "name": "Melhem Melhem"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Assuta Medical Center, Ra'anana, Israel"
      ],
      "name": "Osnat Kalnizki"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Assuta Medical Center, Beer-Sheva, Israel"
      ],
      "name": "Majd Khader"
    },
    {
      "affiliations": [
        "Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel"
      ],
      "name": "Michal Dardik"
    },
    {
      "affiliations": [
        "Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel"
      ],
      "name": "Mifleh Tatour"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Assuta Medical Center, Haifa, Israel",
        "Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel"
      ],
      "name": "Rawi Hazzan"
    }
  ],
  "title": "Association between GLP-1-based therapy and small-bowel transit time during capsule endoscopy: a prospective, multicentre, observational study",
  "uid": "0b6f30ff-0ad4-55f4-8c48-9e9d1240ab0f"
}