{
  "abstract": "Objective Colorectal cancer (CRC) and cardiovascular disease (CVD) share common risk factors. This study explores the association between cardiovascular health (CVH), assessed using the Life’s Essential 8 (LE8) score, and CRC risk, while examining the modifying roles of genetic predisposition and colonoscopy screening.Methods A total of 291 177 UK Biobank participants were included in the analysis. LE8 comprises eight indicators: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Cox proportional hazards models were used for analysis.Results During a median follow-up of 12.97 years, 3791 incident CRC cases were identified. Compared with low LE8 scores, high LE8 scores were associated with a 26% reduced CRC risk (HR: 0.74; 95% CI 0.64 to 0.86). High LE8 was linked to a 27% lower CRC risk in individuals with high genetic risk (HR: 0.73; 95% CI 0.56 to 0.94) and a 35% reduction in those without a history of colonoscopy screening (HR: 0.65; 95% CI 0.54 to 0.78). Joint analysis showed a 78% lower CRC risk in those with high LE8 and low genetic risk (HR: 0.22; 95% CI 0.15 to 0.34).Conclusion Better CVH is associated with a reduced risk of CRC, particularly in individuals with high genetic susceptibility and those without a history of colonoscopy screening.",
  "authors": [
    {
      "affiliations": [
        "Department of Nutrition, Qilu Hospital of Shandong University, Jinan, China"
      ],
      "name": "Chengmiao Qiu"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China"
      ],
      "name": "Mengyang Wang"
    },
    {
      "affiliations": [
        "Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Fujian, China",
        "School of Basic Medicine Science, Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Putian, China"
      ],
      "name": "Shujuan Lin"
    },
    {
      "affiliations": [
        "Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China",
        "Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China"
      ],
      "name": "Yang Zhong"
    },
    {
      "affiliations": [
        "Department of Nutrition, Qilu Hospital of Shandong University, Jinan, China"
      ],
      "name": "Miaomiao Fan"
    },
    {
      "affiliations": [
        "Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China",
        "Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China"
      ],
      "name": "Hao Chen"
    },
    {
      "affiliations": [
        "Department of Nutrition, Qilu Hospital of Shandong University, Jinan, China",
        "Department of Toxicology and Nutrition, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"
      ],
      "name": "Liyong Chen"
    },
    {
      "affiliations": [
        "Department of Nutrition, Qilu Hospital of Shandong University, Jinan, China",
        "Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China",
        "Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China",
        "Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China"
      ],
      "name": "Hao Bai"
    }
  ],
  "title": "Cardiovascular health assessed by Life’s Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank",
  "uid": "7e28b846-bfe6-5ae4-8bba-6f3294654ef1"
}