{
  "abstract": "Objective Extraintestinal manifestations (EIMs) are common in paediatric inflammatory bowel disease (IBD), often impairing quality of life. Our aim was to assess whether EIMs at diagnosis are associated with disease severity in paediatric IBD.Methods We conducted a post hoc analysis from the Hungarian Pediatric IBD Registry (2010–2020), including children with Crohn’s disease (CD) or ulcerative colitis (UC). Outcomes (relapse, steroid dependency, biological therapy (BT), surgery) were compared between patients with EIMs at diagnosis and those without, using Kaplan-Meier and Cox regression analyses.Results Among 1590 patients, EIMs were more frequent in CD than in UC (25% vs 14%, p<0.0001). In CD, EIMs were linked to earlier steroid dependency (p=0.0047) and BT initiation (p=0.00049). Patients without EIMs had a higher risk of intestinal resection (HR 3.2; 95% CI 1.572 to 6.472; p=0.001). In UC, EIMs were not associated with relapse (p=0.600), steroid dependency (p=0.890) or need for BT (p=0.081). Colectomy occurred earlier in the patients with EIMs (p=0.032).Conclusion In patients with CD, EIM at diagnosis more often required BT, but underwent fewer surgeries. In patients with UC, EIMs at diagnosis appeared to be associated with an increased risk of BT and colectomy.",
  "authors": [
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Heim Pál National Pediatric Institute, Budapest, Hungary"
      ],
      "name": "Ágnes Eszter Tímár"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "MRE Bethesda Children’s Hospital, Budapest, Hungary"
      ],
      "name": "Márk Hernádfői"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary",
        "Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary"
      ],
      "name": "Brigitta Teutsch"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "University of Veterinary Medicine, Budapest, Hungary"
      ],
      "name": "Zsolt Abonyi-Tóth"
    },
    {
      "affiliations": [
        "Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary",
        "Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary"
      ],
      "name": "Nelli Farkas"
    },
    {
      "affiliations": [
        "Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary",
        "Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary"
      ],
      "name": "Zoltán Sipos"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary",
        "Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Péter Hegyi"
    },
    {
      "affiliations": [
        "Heim Pál National Pediatric Institute, Budapest, Hungary"
      ],
      "name": "Anna Karoliny"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Heim Pál National Pediatric Institute, Budapest, Hungary"
      ],
      "name": "Andrea Párniczky"
    },
    {
      "affiliations": [
        "Pediatric Center, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Áron Cseh"
    },
    {
      "affiliations": [
        "Pediatric Center, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Antal Dezsőfi"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Pediatric Center, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Miklós Garami"
    },
    {
      "affiliations": [
        "MRE Bethesda Children’s Hospital, Budapest, Hungary"
      ],
      "name": "Judit Czelecz"
    },
    {
      "affiliations": [
        "Jósa András Hospital, Nyíregyháza, Hungary"
      ],
      "name": "Ildikó Guthy"
    },
    {
      "affiliations": [
        "Petz Aladár University Teaching Hospital of Győr-Moson-Sopron County, Győr, Hungary"
      ],
      "name": "Márta Kovács"
    },
    {
      "affiliations": [
        "Csolnoky Ferenc Hospital, Veszprém, Hungary"
      ],
      "name": "Ágnes Horváth"
    },
    {
      "affiliations": [
        "Markusovszky Hospital, Szombathely, Hungary"
      ],
      "name": "Márta Balogh"
    },
    {
      "affiliations": [
        "Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary"
      ],
      "name": "András Tárnok"
    },
    {
      "affiliations": [
        "Department of Pediatrics, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary"
      ],
      "name": "Dániel Szűcs"
    },
    {
      "affiliations": [
        "Department of Pediatrics, Clinical Center, University of Debrecen, Debrecen, Hungary"
      ],
      "name": "Orsolya Kadenczki"
    },
    {
      "affiliations": [
        "Borsod-Abaúj-Zemplén County Hospital and University Teaching Hospital, Pediatric Healthcare Centre, Miskolc, Hungary"
      ],
      "name": "Éva Kosaras"
    },
    {
      "affiliations": [
        "Department of Pediatrics, North-Buda Saint John’s Central Hospital, Budapest, Hungary"
      ],
      "name": "Natália Lásztity"
    },
    {
      "affiliations": [
        "Heim Pál National Pediatric Institute, Budapest, Hungary",
        "Department of Family Care Methodology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Katalin Eszter Müller"
    }
  ],
  "title": "Association of extraintestinal manifestations and disease severity in paediatric inflammatory bowel disease: a multicentre cohort study",
  "uid": "ff06021c-5906-5e90-985e-96606b08359c"
}