{
  "abstract": "Objective Upadacitinib is the first Janus kinase inhibitor and oral advanced therapy licensed for Crohn’s disease (CD). Following NICE approval in 2023, real-world data on outcomes are limited. The effectiveness and safety of upadacitinib in a cohort of patients with CD was assessed.Methods A multicentre retrospective cohort analysis across 19 UK hospitals. Adult patients with active CD who started upadacitinib between April 2023 and October 2023 were included. Outcomes were reviewed over 24 weeks. The primary endpoint was clinical remission (Harvey Bradshaw Index (HBI) <4) at 12 and 24 weeks. Biochemical remission (faecal calprotectin <200 μg/g and C-reactive protein ≤5) and endoscopic remission (Simple Endoscopic Score for Crohn’s Disease ≤3) were assessed at the same intervals. Adverse events (AEs) were recorded until 24 weeks or drug withdrawal.Results 312 patients were included, with a minimum follow-up of 12 weeks. The cohort had difficult-to-treat disease; 64% failing 3 or more biologics, 51% exhibiting penetrating or stricturing disease and 41% requiring prior resection. 50% (113/227) of patients achieved clinical remission at 12 weeks and 45% (77/172) at 24 weeks. Patients with colonic disease had higher remission rates at 24 weeks compared with other disease locations. At 24 weeks, 51 patients (16%) had discontinued upadacitinib. Treatment persistence was 90.3% at 12 weeks and 84.1% at 24 weeks. 28% had AEs, with 18% experiencing serious AEs and 16.6% requiring hospitalisation.Conclusion This is a large real-world study reporting outcomes in patients with CD treated with upadacitinib. Our data demonstrated good short-term effectiveness and tolerance in a clinically refractory population.",
  "authors": [
    {
      "affiliations": [
        "Barts Health NHS Trust, London, UK"
      ],
      "name": "Yaa Danso"
    },
    {
      "affiliations": [
        "King’s College Hospital NHS Foundation Trust, London, UK",
        "King’s College London Faculty of Life Sciences & Medicine, London, UK"
      ],
      "name": "Chandni Radia"
    },
    {
      "affiliations": [
        "Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK",
        "The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia"
      ],
      "name": "Alex Elford"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Jie Han Yeo"
    },
    {
      "affiliations": [
        "Barts Health NHS Trust, London, UK"
      ],
      "name": "Thomas Morris"
    },
    {
      "affiliations": [
        "Guy's and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Chirag Patel"
    },
    {
      "affiliations": [
        "Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"
      ],
      "name": "Kimberley Butler"
    },
    {
      "affiliations": [
        "St George’s University Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Sonia Kalyanji"
    },
    {
      "affiliations": [
        "St Mark’s the National Bowel Hospital and Academic Institute, London, UK"
      ],
      "name": "Katie Yeung"
    },
    {
      "affiliations": [
        "Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"
      ],
      "name": "Chaonan Dong"
    },
    {
      "affiliations": [
        "Gastroenterology, Northern Care Alliance NHS Foundation Trust, Manchester, UK"
      ],
      "name": "Karishma Sethi-Arora"
    },
    {
      "affiliations": [
        "Leeds Teaching Hospitals NHS Trust, Leeds, England, UK"
      ],
      "name": "Alice Hewitt"
    },
    {
      "affiliations": [
        "Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Lushen Pillay"
    },
    {
      "affiliations": [
        "County Durham and Darlington NHS Foundation Trust, Darlington, UK"
      ],
      "name": "Susan Ritchie"
    },
    {
      "affiliations": [
        "Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, UK"
      ],
      "name": "Mohammed Allah-Ditta"
    },
    {
      "affiliations": [
        "Imperial College Healthcare NHS Trust, London, UK"
      ],
      "name": "Lucy Hicks"
    },
    {
      "affiliations": [
        "Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK"
      ],
      "name": "Phil Harvey"
    },
    {
      "affiliations": [
        "University Hospitals Sussex NHS Foundation Trust, Worthing, UK"
      ],
      "name": "Fiona Rees"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"
      ],
      "name": "Emma Johnston"
    },
    {
      "affiliations": [
        "Mid Yorkshire Teaching NHS Trust, Wakefield, UK"
      ],
      "name": "Ruth Rudling"
    },
    {
      "affiliations": [
        "Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK",
        "Centre for genomics and experimental medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK"
      ],
      "name": "Charlie Lees"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Jennifer Toft"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Sara Mccartney"
    },
    {
      "affiliations": [
        "Guy's and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Xinyi Choon"
    },
    {
      "affiliations": [
        "St George’s University Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Richard C G Pollok"
    },
    {
      "affiliations": [
        "St Mark’s the National Bowel Hospital and Academic Institute, London, UK"
      ],
      "name": "Dania Al-Zarrad"
    },
    {
      "affiliations": [
        "Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"
      ],
      "name": "Melissa Hale"
    },
    {
      "affiliations": [
        "Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK",
        "Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Christopher Andrew Lamb"
    },
    {
      "affiliations": [
        "Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK",
        "Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "R Alexander Speight"
    },
    {
      "affiliations": [
        "Gastroenterology, Northern Care Alliance NHS Foundation Trust, Manchester, UK"
      ],
      "name": "Jimmy Limdi"
    },
    {
      "affiliations": [
        "Leeds Teaching Hospitals NHS Trust, Leeds, England, UK"
      ],
      "name": "Hannah Trodden-Mittnacht"
    },
    {
      "affiliations": [
        "Leeds Teaching Hospitals NHS Trust, Leeds, England, UK"
      ],
      "name": "Konstantina Rosiou"
    },
    {
      "affiliations": [
        "Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Tim Raine"
    },
    {
      "affiliations": [
        "Gastroenterology, County Durham and Darlington NHS Foundation Trust, Darlington, UK",
        "School of Health and Life Sciences, Teesside University, Middlesbrough, UK"
      ],
      "name": "Anjan Dhar"
    },
    {
      "affiliations": [
        "Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, UK"
      ],
      "name": "Puneet Chhabra"
    },
    {
      "affiliations": [
        "Mid Yorkshire Teaching NHS Trust, Wakefield, UK"
      ],
      "name": "Nick N Burr"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Paul Harrow"
    },
    {
      "affiliations": [
        "St George’s University Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Kamal V Patel"
    },
    {
      "affiliations": [
        "Guy's and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Mark Samaan"
    },
    {
      "affiliations": [
        "King’s College Hospital NHS Foundation Trust, London, UK"
      ],
      "name": "Polychronis Pavlidis"
    },
    {
      "affiliations": [
        "King’s College Hospital NHS Foundation Trust, London, UK"
      ],
      "name": "Alexandra Kent"
    },
    {
      "affiliations": [
        "Barts Health NHS Trust, London, UK"
      ],
      "name": "Klaartje Bel Kok"
    },
    {
      "affiliations": [
        "Leeds Teaching Hospitals NHS Trust, Leeds, England, UK"
      ],
      "name": "Christian Selinger"
    }
  ],
  "title": "Effectiveness and safety of upadacitinib in a real-world cohort of patients with Crohn’s disease in the UK: a multicentre retrospective cohort study",
  "uid": "8c473a39-0a81-5655-bb9b-c888e49708fe"
}