{
  "abstract": "The prevalence of diabetes is increasing globally. The International Diabetes Federation reported that the number of diabetes cases reached 425 million in 2017, and this is predicted to total 693 million globally by 2045. Most increases in the diabetic patients were type 2 (T2D), supposed to be due to the changes in lifestyle including overeating, obesity, low exercise, and aging. On the other hand, the number of type 1 diabetes (T1D) mainly caused by the autoimmunity against pancreatic β-cells is increasing at 3% every year. The rate of increase of T1D due to autoimmunity cannot explain the increasing level of T1D. Environmental factors including toxins and viruses are also considered to be responsible for the increasing prevalence of T1D.1 2",
  "authors": [
    {
      "affiliations": [
        "Division of Metabolism and Endocrinology, Saga University Faculty of Medicine Graduate School of Medical Sciences, Saga, Saga, Japan"
      ],
      "name": "Seiho Nagafuchi"
    },
    {
      "affiliations": [
        "Department of Medicine, Boston College, Chestnut Hill, Massachusetts, USA"
      ],
      "name": "Keiichiro Mine"
    },
    {
      "affiliations": [
        "Division of Metabolism and Endocrinology, Saga University Faculty of Medicine Graduate School of Medical Sciences, Saga, Saga, Japan"
      ],
      "name": "Rasheda Perveen"
    },
    {
      "affiliations": [
        "Division of Metabolism and Endocrinology, Saga University Faculty of Medicine Graduate School of Medical Sciences, Saga, Saga, Japan"
      ],
      "name": "Hitoe Mori"
    },
    {
      "affiliations": [
        "Diabetes and Endocrinology, Takagi Hospital, Ohkawa, Fukuoka, Japan"
      ],
      "name": "Keizo Anzai"
    },
    {
      "affiliations": [
        "Division of Metabolism and Endocrinology, Saga University Faculty of Medicine Graduate School of Medical Sciences, Saga, Saga, Japan",
        "Liver Center, Saga University Hospital, Saga, Saga, Japan"
      ],
      "name": "Hirokazu Takahashi"
    }
  ],
  "title": "Significance of the tyrosine kinase 2 gene in both type 1 and type 2 diabetes",
  "uid": "5d51d934-7922-5eb7-b33f-0f6116d7198c"
}