{
  "abstract": "A female in her early 20s with bilateral congenital aniridia-associated keratopathy (AAK) and progressive limbal stem cell deficiency (LSCD) presented with recurrent epithelial defects in the left eye for which she underwent cadaveric allogeneic simple limbal epithelial transplantation (allo-SLET) with lateral paramedian tarsorrhaphy. Postoperatively, topical and systemic immunosuppression with topical corticosteroids and oral cyclosporine was initiated. The ocular surface stabilised after surgery; however, an episode of epithelial rejection occurred at 4 months which resolved with intensified corticosteroid therapy and intravenous methylprednisolone. Subsequent cataract surgery was performed and the ocular surface remained stable. Best-corrected visual acuity improved from 20/600 to 20/160 and remained stable over a 2.5-year follow-up. This case highlights allo-SLET as an effective option for advanced bilateral AAK and the need for long term immunosuppression to prevent episodes of epithelial rejection and recurrence of LSCD.",
  "authors": [
    {
      "affiliations": [
        "Cornea and Anterior Segment, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"
      ],
      "name": "Shilpa Tarini"
    },
    {
      "affiliations": [
        "Cornea and Anterior Segment, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"
      ],
      "name": "Nikita Das"
    },
    {
      "affiliations": [
        "Academy For Eye Care Education, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"
      ],
      "name": "Praful Rag"
    }
  ],
  "title": "Allogeneic simple limbal epithelial transplantation (SLET) in aniridia-associated keratopathy",
  "uid": "bdc359a8-1410-5550-ada3-6fcda4e71592"
}