{
  "abstract": "Immune checkpoint inhibitor colitis is a common immune-related adverse event associated with immunotherapy and may be refractory to corticosteroids and biologic therapy. Evidence guiding management beyond anti-tumour necrosis factor and anti-integrin therapy remains limited. We report a case of severe immune checkpoint inhibitor colitis in a man in his 60s with metastatic melanoma treated with combination ipilimumab and nivolumab. Colitis was refractory to corticosteroids, dose-escalated infliximab and vedolizumab. Upadacitinib was commenced with rapid improvement, with stool frequency decreasing from 40 bowel motions per day to 6 within 24 hours. This response was accompanied by a marked decrease in C-reactive protein and faecal calprotectin. His recovery was complicated by cytomegalovirus infection, successfully treated with valganciclovir. A repeat colonoscopy demonstrated complete mucosal healing and the patient achieved durable steroid-free remission following treatment cessation. This case illustrates the potential role of Janus kinase 1 inhibition as a salvage strategy in refractory immune checkpoint inhibitor colitis.",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia",
        "Department of Gastroenterology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"
      ],
      "name": "Faris Gondal"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia",
        "Department of General Medicine, The Northern Hospital, Epping, Victoria, Australia"
      ],
      "name": "Joshua Haron Abasszade"
    },
    {
      "affiliations": [
        "Department of Pathology, The Royal Melbourne Hospital, Parkville, Victoria, Australia"
      ],
      "name": "Anand Murugasu"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia",
        "Department of Gastroenterology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia",
        "School of Medicine, The University of Melbourne, Parkville, Victoria, Australia"
      ],
      "name": "Jonathan P Segal"
    }
  ],
  "title": "Upadacitinib salvage for refractory immune checkpoint inhibitor colitis complicated by cytomegalovirus infection",
  "uid": "e011fde2-eaa3-54d5-a79b-92c808f03a7d"
}